Protein Info for HP15_186 in Marinobacter adhaerens HP15

Annotation: two-component sensor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 451 signal peptide" amino acids 12 to 13 (2 residues), see Phobius details amino acids 33 to 35 (3 residues), see Phobius details transmembrane" amino acids 14 to 32 (19 residues), see Phobius details amino acids 161 to 184 (24 residues), see Phobius details PF14501: HATPase_c_5" amino acids 340 to 440 (101 residues), 29.4 bits, see alignment E=6.4e-11 PF02518: HATPase_c" amino acids 342 to 444 (103 residues), 64 bits, see alignment E=1.6e-21

Best Hits

KEGG orthology group: None (inferred from 75% identity to maq:Maqu_0123)

Predicted SEED Role

"Sensor protein PhoQ (EC 2.7.13.3)" in subsystem Lipid A modifications (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK19 at UniProt or InterPro

Protein Sequence (451 amino acids)

>HP15_186 two-component sensor (Marinobacter adhaerens HP15)
MTLFSKPKSVKGTLLLLLLPAGIALMGLAWLVHGLLLDRMSREFVETRLKDEVAFLEHQI
LDSGGQLDSLQTGDYFQEVFHHAFAIHSPSRTIISPDSWAPVLTSLIESAKDGTVRVRDA
DTVEGPKNILAYRKSFQIGDTPIVVIVSEDLGALKRSQAELHAWTAIVSILLILLLVVVI
WFGINLSMRPVVELKATLKRLQDGKVSRIHVQAPEEFRPLVQQLNQLLDSLDQRLERSRD
ALANLSHSVKTPIAAVRQILEDTSRPLSNDLRLQMTARLNDIDKQLEAEMRRSRFAGPQV
GKSAYPLKQARDLLWMLGRLYPEKSFELSSSLPEDARWPIEEHDLNEIMGNLLDNAGKWS
DHCVELSLVQRSGTLQMGVIDDGPGVADAEISKLGQRGLRLDEQTPGHGLGLAIVREIVE
RYGGTLRFPTIPERGFSVVVNLPKSASVISH