Protein Info for Psest_1859 in Pseudomonas stutzeri RCH2

Annotation: Glutathione S-transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02798: GST_N
  • amino acids 4 to 74 (71 residues), 50.3 bits, E=7.3e-17
• PF13417: GST_N_3
  • amino acids 12 to 79 (68 residues), 39.6 bits, E=1.6e-13
• PF13409: GST_N_2
  • amino acids 12 to 74 (63 residues), 51.2 bits, E=4.9e-17
• PF14497: GST_C_3
  • amino acids 140 to 208 (69 residues), 26.4 bits, E=1.9e-09
• PF00043: GST_C
  • amino acids 145 to 207 (63 residues), 31 bits, E=7.6e-11
• PF13410: GST_C_2
  • amino acids 146 to 202 (57 residues), 29.2 bits, E=2.4e-10

Best Hits

KEGG orthology group: K00799, glutathione S-transferase [EC: 2.5.1.18] (inferred from 87% identity to psa:PST_2471)

Predicted SEED Role

"Glutathione S-transferase (EC 2.5.1.18)" in subsystem Glutathione: Non-redox reactions (EC 2.5.1.18)

MetaCyc Pathways

• 4-hydroxy-2-nonenal detoxification (1/4 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• pentachlorophenol degradation (3/10 steps found)
• gliotoxin biosynthesis (1/9 steps found)
• glutathione-mediated detoxification II (1/9 steps found)
• indole glucosinolate activation (intact plant cell) (3/12 steps found)
• camalexin biosynthesis (2/12 steps found)

KEGG Metabolic Maps

• Drug metabolism - cytochrome P450
• Glutathione metabolism
• Metabolism of xenobiotics by cytochrome P450

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.18

Use Curated BLAST to search for 2.5.1.18

Sequence Analysis Tools

See L0GLZ2 at UniProt or InterPro

Protein Sequence (223 amino acids)

>Psest_1859 Glutathione S-transferase (Pseudomonas stutzeri RCH2)
MITVHHLNHSRSHRVLWLMEELELLYELKRYPRDPKTMLAPAELKAVHPLGKSPVITDGE
LTLAESAAILEYLLERYGNGRLAPQSSSAEYRRFRYWMHYAEGSAMPPMLLKLVFDRVAT
GPMPFFIRPVARAIAKGANRAFIGPQLKTHLDYMEAELGKSDWFAGDNFSAADIQMSFPI
EAARARAGLDESRPRLMNFLQRIQQRPAYKRAVERGGPALPAA