Protein Info for HP15_1691 in Marinobacter adhaerens HP15

Annotation: ATPase AAA-2 domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 912 PF02861: Clp_N" amino acids 117 to 161 (45 residues), 24.7 bits, see alignment 1.2e-08 amino acids 190 to 241 (52 residues), 46.8 bits, see alignment 1.5e-15 PF00004: AAA" amino acids 300 to 415 (116 residues), 57.1 bits, see alignment E=1.5e-18 amino acids 641 to 762 (122 residues), 32.6 bits, see alignment E=5.6e-11 PF17871: AAA_lid_9" amino acids 442 to 541 (100 residues), 115.8 bits, see alignment E=4.5e-37 PF07724: AAA_2" amino acids 634 to 803 (170 residues), 224.4 bits, see alignment E=4.8e-70 PF00158: Sigma54_activat" amino acids 637 to 757 (121 residues), 28 bits, see alignment E=9.2e-10 PF07728: AAA_5" amino acids 639 to 760 (122 residues), 41.3 bits, see alignment E=8.6e-14 PF10431: ClpB_D2-small" amino acids 809 to 888 (80 residues), 74.1 bits, see alignment E=4.2e-24

Best Hits

KEGG orthology group: K03696, ATP-dependent Clp protease ATP-binding subunit ClpC (inferred from 61% identity to dth:DICTH_0749)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PN06 at UniProt or InterPro

Protein Sequence (912 amino acids)

>HP15_1691 ATPase AAA-2 domain protein (Marinobacter adhaerens HP15)
MGKSAEQSPQVSCDICRQRPAALQVTVSQAGRRRTLNVCQTDYLRLRARSASPFESLFGS
GLHSDDFFERLARDEDFGFGSVASRENGRPQDSESIALGDLLSEQSEQILQQAAATAAEW
GSQLIDTSHLLYALADNDVVQALLKRYQLSARDLKTQVEQLTPKGASEPETDGPAKIGVS
PRVKAALQHAFQASRDLGHGYIGPEHLLIGLAEEEGLASDLLNRYGLSAHSLRQKTVQVV
GKGAQEGRLPEQSDTPTLDKYSRDLTALANEGKLDPVIGRAAEVESLIEVLSRRRKNNPV
LIGEPGVGKTAIVEGLAQRIVHNEVPDLLQNKRVVELNINSLVAGSQYRGQFEERIKQVL
DEITSHQNKIVLFIDELHTIVGAGSTGGEGGLDVANTLKPQLARGELHLVGATTLAEYQK
HIEKDAALERRLQPVFVAEPTIDQTINILRGLRDRLEAHHKVTITDEAIVAAVEMADRYV
TNRFLPDKAIDLIDQAAARVRIGGTSRPPELHELGAQIDQLRRERDYASNRKDFERASAL
EARIEEHQGDYDQGLEEWNTTRSTSANQVDVEDVAQIVSRLTGVPVAELTTEERTRLMEM
EQRLHQRVVGQDEAVTAVSDAVRLSRAGLGDRRRPIATFFFLGPTGVGKTELTKALAETV
FGDEEAMIRIDMSEYMERHTVARLIGAPPGYVGHEEGGQLTEKVRRKPYSVVLLDEFEKA
HMDVQNVLLQVFEDGRLTDGKGRVVDFTNTIIIATSNIGSDVIRENIEAPEDKRKDDAEL
KSELLNVLRRYLRPEFINRIDEIIVFHALDRKQIGDIVGLQLERVKRIAHGQGLTVEFDD
SLIDHLADVGYRPEFGARELRRQIRSLIETRLASAVLRGDIEEGDSLRFVYDEGRSEIRW
EKEAKVPASEPE