Protein Info for HP15_1689 in Marinobacter adhaerens HP15

Annotation: sensory box/GGDEF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 685 PF08448: PAS_4" amino acids 22 to 125 (104 residues), 57.9 bits, see alignment E=3.9e-19 amino acids 138 to 224 (87 residues), 30.5 bits, see alignment E=1.3e-10 TIGR00229: PAS domain S-box protein" amino acids 22 to 130 (109 residues), 47.9 bits, see alignment E=1.4e-16 amino acids 137 to 248 (112 residues), 57.2 bits, see alignment E=1.9e-19 PF13426: PAS_9" amino acids 23 to 122 (100 residues), 33 bits, see alignment E=2.2e-11 amino acids 143 to 240 (98 residues), 41 bits, see alignment E=6.9e-14 PF00989: PAS" amino acids 135 to 229 (95 residues), 47 bits, see alignment E=8.2e-16 PF13188: PAS_8" amino acids 136 to 184 (49 residues), 32.8 bits, see alignment 1.6e-11 PF08447: PAS_3" amino acids 155 to 233 (79 residues), 25.9 bits, see alignment E=3.4e-09 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 252 to 413 (162 residues), 116.7 bits, see alignment E=8.6e-38 PF00990: GGDEF" amino acids 255 to 410 (156 residues), 137 bits, see alignment E=1.8e-43 PF00563: EAL" amino acids 432 to 666 (235 residues), 266 bits, see alignment E=9.5e-83

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PN04 at UniProt or InterPro

Protein Sequence (685 amino acids)

>HP15_1689 sensory box/GGDEF family protein (Marinobacter adhaerens HP15)
MTENHMHEVMDRLSPSVFAGLLTVDGVLTYANKAALDAIGAQAEEVLGRPFDATPWWRFS
DQSRQRLRESIRAAGRGLASRFDVPILDLNGRVRTMDFTLHPVYDDNGNVTYLVPSGRDI
TERRQAERELRLTQFAVDHARGAMFQIDADGRVRYANRAACDMLGYAREDLTGRLLSDID
PTMTEGVWREHLHELKAQGSARLESLARRSDGGLIPIEVTATYIEYEGEPVSFSYVDDLT
ARRASEERIHYLTRFDGLTRLPNRTALHERLEQAIESAQHSNSSVALLIVGLDRLGLVND
ALGHAGGDEVLRAIAERLSACAETPATVARIGGDEFAIMYTTDTQQDLHAEYWIQRILES
VSEPLRIDDQEICLTCSIGSAAYPTDGTDSGELFKNASSALRCAKGRGRNMHQAYAIATA
NRDPERLFLESALRGAQKYGEFSVHYQPRIDVDTGAPVGAEALLRWHHPDKGMISPARFI
PIAEETGLIESIGEWVLRAACEQNRLWRESDLKPGRIGVNLSARQFRHADLALRVVQLLK
ESGLDPEHLELEITESMLMEDVDAAITTMTCLKDYGVSIALDDFGTGYSCLSYLKRFPID
TLKIDQSFVREITSDPASAAIADAIIAMAQRLGLDVIAEGVETPEQCRLLRESGCRLMQG
YLFARPVPAEDLTKLLRVGNLGKHL