Protein Info for PGA1_c17520 in Phaeobacter inhibens DSM 17395

Annotation: putative peptidyl-prolyl cis-trans isomerase A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 168 PF00160: Pro_isomerase" amino acids 11 to 164 (154 residues), 146.4 bits, see alignment E=4.5e-47

Best Hits

Swiss-Prot: 58% identical to PPI1_BRUSU: Probable peptidyl-prolyl cis-trans isomerase (ppi) from Brucella suis biovar 1 (strain 1330)

KEGG orthology group: K01802, peptidylprolyl isomerase [EC: 5.2.1.8] (inferred from 93% identity to sil:SPO2234)

MetaCyc: 64% identical to glucuronan lyase (Sinorhizobium meliloti Rm2011)
Glucuronan lyase. [EC: 4.2.2.14]

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 4.2.2.14 or 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EXA3 at UniProt or InterPro

Protein Sequence (168 amino acids)

>PGA1_c17520 putative peptidyl-prolyl cis-trans isomerase A (Phaeobacter inhibens DSM 17395)
MAEIKDPENTIIMELKDGKVVIELLPDVAPQHSARMKELARSGAYDNVAFHRVIDGFMAQ
TGDVQHGDMEDGFNLRMAGTGGSDLPNVPAEFSKLPHDRGTLGAARSANPDSANSQFFIN
FKDNHFLNGQYTVYGRVIEGMEHVDAITRGEPPANPDRMVSVKVAADV