Protein Info for PGA1_c16860 in Phaeobacter inhibens DSM 17395

Annotation: anthranilate synthase component 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00564: anthranilate synthase component I
  • amino acids 29 to 491 (463 residues), 561.3 bits, E=9.6e-173
• PF04715: Anth_synt_I_N
  • amino acids 29 to 174 (146 residues), 105.8 bits, E=2.3e-34
• PF00425: Chorismate_bind
  • amino acids 230 to 483 (254 residues), 305.2 bits, E=4.2e-95

Best Hits

Swiss-Prot: 77% identical to TRPE_RHOS4: Anthranilate synthase component 1 (trpE) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: K01657, anthranilate synthase component I [EC: 4.1.3.27] (inferred from 92% identity to sit:TM1040_1143)

Predicted SEED Role

"Anthranilate synthase, aminase component (EC 4.1.3.27)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Tryptophan synthesis (EC 4.1.3.27)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-citrulline biosynthesis (8/8 steps found)
• L-glutamate and L-glutamine biosynthesis (7/7 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• superpathway of L-citrulline metabolism (10/12 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (4/4 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• 4-hydroxy-2(1H)-quinolone biosynthesis (3/5 steps found)
• acridone alkaloid biosynthesis (1/4 steps found)
• superpathway of quinolone and alkylquinolone biosynthesis (3/10 steps found)
• superpathway of chorismate metabolism (36/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.27

Use Curated BLAST to search for 4.1.3.27

Sequence Analysis Tools

See I7EX50 at UniProt or InterPro

Protein Sequence (503 amino acids)

>PGA1_c16860 anthranilate synthase component 1 (Phaeobacter inhibens DSM 17395)
MALTPDFDTFAKAYEAGENQVVYTRLAADLDTPVSLMLKLTGAQKDAFILESVTGGEVRG
RYSIIGMKPDLVWRCHGERAALNRSARFDADAFEPLDGNPLDCLRDLIAESKIDLPDDLP
QAAAGLFGYLGYDMIRLVEHLPDVNPDPLGLPDALMLRPSVIAVLDGVKGEVTVVSPAWA
SDGQSAKAAYAQAAERVMDAVRDLERAMPAESRDLGDADEVAPPVSNFTKDGYMAAVEKA
KDYIRAGDIFQVVPAQRWTQTFRQPPFALYRSLRRTNPSPFMFYFNFGGFQVVGASPEIL
VRVFGQEVTIRPIAGTRPRGATPEEDKALELDLLADKKELAEHLMLLDLGRNDTGRVAKI
GTVRPTEKFIIERYSHVMHIVSNVVGELAEDKDALDAFFAGMPAGTVSGAPKVRAMEIID
ELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAIVKDQNLYIQAGGGVVYDSDPEAEYMET
VHKSNAIRRAAADAARFTGNGNS