Protein Info for PGA1_c16800 in Phaeobacter inhibens DSM 17395
Annotation: pyridoxine/pyridoxamine 5'-phosphate oxidase PdxH
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 81% identical to PDXH_RUEPO: Pyridoxine/pyridoxamine 5'-phosphate oxidase (pdxH) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
KEGG orthology group: K00275, pyridoxamine 5'-phosphate oxidase [EC: 1.4.3.5] (inferred from 81% identity to sil:SPO2141)Predicted SEED Role
"Pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.4.3.5)
MetaCyc Pathways
- pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
- pyridoxal 5'-phosphate salvage II (plants) (5/9 steps found)
- superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)
- pyridoxal 5'-phosphate salvage I (2/6 steps found)
- 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II (2/8 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.4.3.5
Use Curated BLAST to search for 1.4.3.5
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See I7DQP1 at UniProt or InterPro
Protein Sequence (201 amino acids)
>PGA1_c16800 pyridoxine/pyridoxamine 5'-phosphate oxidase PdxH (Phaeobacter inhibens DSM 17395) MSDRSGIFAGEDPFAIARSWLSEAEESEINDPNAIALSTVDADGLPNCRMVLLKEIEDAA FVFYTNYESAKAQELDGAGKAAFVMHWKSLRRQVRARGIITRENGPQADEYYKSRSLKSR LGAWASAQSRPLSSRGALMAEVAKVTATKGSNPDRPPFWGGYRLTPLEIEFWADGAFRLH DRFVWRRETPEALWTVDRLCP