Protein Info for Psest_1691 in Pseudomonas stutzeri RCH2

Annotation: aminodeoxychorismate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03461: aminodeoxychorismate lyase
  • amino acids 5 to 263 (259 residues), 285.5 bits, E=1.7e-89
• PF01063: Aminotran_4
  • amino acids 26 to 247 (222 residues), 167.5 bits, E=2.1e-53

Best Hits

Swiss-Prot: 39% identical to PABC_ECOLI: Aminodeoxychorismate lyase (pabC) from Escherichia coli (strain K12)

KEGG orthology group: K02619, 4-amino-4-deoxychorismate lyase [EC: 4.1.3.38] (inferred from 80% identity to psa:PST_2619)

MetaCyc: 39% identical to aminodeoxychorismate lyase (Escherichia coli K-12 substr. MG1655)
Aminodeoxychorismate lyase. [EC: 4.1.3.38]

Predicted SEED Role

"Aminodeoxychorismate lyase (EC 4.1.3.38)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 4.1.3.38)

MetaCyc Pathways

• superpathway of chorismate metabolism (44/59 steps found)
• superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
• superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
• 4-aminobenzoate biosynthesis I (2/2 steps found)
• 4-aminobenzoate biosynthesis II (1/2 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.38

Sequence Analysis Tools

See L0GJQ5 at UniProt or InterPro

Protein Sequence (273 amino acids)

>Psest_1691 aminodeoxychorismate lyase (Pseudomonas stutzeri RCH2)
MTSSWLNGQPCIGLPVHDRGLAYGDGLFETIRVADSQAPLLDRHLQRLRDGCQRLAIPID
TDELRNELARFFPVLGRGVAKLIVTRGTGQRGYAPPEPCQPQRLLLGSPLPAYPPQNALA
GIRLFPCETRLAEQPRLAGIKHLNRLEQVLARAEWHDPAYAEGLMRDMSGRVVEGVFSNL
FMVVDGELRTASLVRCGVAGVMRAEIMARASQHGRTVVESDISYAELLQADEVFLCNSLY
GIWPVTALAERVWPVGPLTRKLQAVVADLLSDP