Protein Info for PGA1_c16670 in Phaeobacter inhibens DSM 17395

Updated annotation (from data): D-mannose isomerase (EC 5.3.1.7)
Rationale: Specifically important for: D-Mannose. often annotated as N-acylglucosamine 2-epimerase, but the phenotype confirms that it is mannose isomerase.
Original annotation: putative N-acylglucosamine 2-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07221: GlcNAc_2-epim
  • amino acids 46 to 392 (347 residues), 351.3 bits, E=3.4e-109

Best Hits

KEGG orthology group: None (inferred from 48% identity to rsk:RSKD131_2676)

Predicted SEED Role

"N-acylglucosamine 2-epimerase (EC 5.1.3.8)" in subsystem Sialic Acid Metabolism (EC 5.1.3.8)

MetaCyc Pathways

• N-acetylneuraminate and N-acetylmannosamine degradation II (1/3 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Fructose and mannose metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.8 or 5.3.1.7

Sequence Analysis Tools

See I7E0Z4 at UniProt or InterPro

Protein Sequence (417 amino acids)

>PGA1_c16670 D-mannose isomerase (EC 5.3.1.7) (Phaeobacter inhibens DSM 17395)
MSTHSAVGDLSAPGVWLEDTGHQAYLIADARRQLDFFAGSLRAEPGFHTLDAAGRPLPDD
KQELHTTTRLVHSYALAHICGYAGAEQMIDHGMAYLNSHHRDQIHGGYLWALSGDAIADD
RKLAYGHVFVLLAAASAKLAGHPGADALLSDVAEVLDQRFWETGPKRFADEWNRDWTPFS
TYRGMNANMHGVEALLTAYEATGETVFLDRAGHILDFFVDEVAAAESWRLPEHYTETWQI
DRTYAGDPMFRPAGTTPGHSFELGRLMLQHWDLAGRRDTGAPTRARSLIEQALADAWLVD
GGFAYTLDFEGKVAMRNRFWWPVTEAIGAVATLVKLDGRVEDEQWYRRLWGFAQAHFIDE
DRGGWYPEIDGNGQVTRTIFTGKPDIYHALQACLLPLGALPLGHVAGLKKLSAPLLS