Protein Info for HP15_1582 in Marinobacter adhaerens HP15

Annotation: type III restriction enzyme, res subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1009 PF04313: HSDR_N" amino acids 136 to 230 (95 residues), 58.4 bits, see alignment E=1.9e-19 PF04851: ResIII" amino acids 295 to 491 (197 residues), 61.6 bits, see alignment E=1.8e-20 PF18766: SWI2_SNF2" amino acids 298 to 539 (242 residues), 85.5 bits, see alignment E=9e-28 PF00270: DEAD" amino acids 316 to 494 (179 residues), 35.7 bits, see alignment E=1.4e-12

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 87% identity to gpb:HDN1F_11660)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PM18 at UniProt or InterPro

Protein Sequence (1009 amino acids)

>HP15_1582 type III restriction enzyme, res subunit (Marinobacter adhaerens HP15)
MVSQTNEQALEAAIERALTGLTTEAVKQAGKVKETPADDLVANNGFQLGLPYDFNAQYAI
DEKLFWRFLEQTQGKELAKLKKHNSTDWDRKLLERYDRLIKKHGILHLLKKGLAVDDAHF
HLMYPAPLASSSEKVKQNYAANIFSCTRQVRYSLANPLQEIDMVLFLNGIPLVTMELKNA
WTGQTARYHGQKQYRENRDTNQPLLNFARCLVHMAVDTDEVYMTTKLNGKSTFFLPFNKG
HNHGKGNPPNPHGHKSSYLWEEVFTKDSLVNIIQHFVRLDGSSKDPLRKRTLFFPRYHQM
DVVRKLVAHAEDHGVGHTYLIQHSAGSGKSNSITWAAYQLIETYPKNDAAAGGKDQDQPL
FDSVIVVTDRRLLDKQIRENIKEFSEVKNIVAPAFKSSELKSALESGKKIIITTIQKFPF
IVEGIEDLGDKRFAVIIDEAHSSQSGSAHDNMNRAMGQEDDEDEQDKILKAMRSRKMRGN
ASYMAFTATPKNTTFEKFGEKQDDGTFREFHLYSMKQAIEEGFILDVLANYTTYKSYYEI
EKSIAENPQFDTKKAQKKLRAYVESSQQTINTKAEIMLEHFIPQVVNTKKLKGKAKGMVV
TQNIETAIRYHRAISRILEKNGNPFKALVAFSGTKEVDGIEYTEADINGFSENDTKDKFD
TDEYRLLVVANKYLTGFDQPKLCAMYVDKKLASVMCVQTLSRLNRAAPKLGKKTEDLFIL
DFFNTTDDIKTAFDPFYTATSLSGATDVNVLHELKDAMDEVGVYEWHEVEDFVARYFDGE
DAQNLSPIIDVAASRFEHELELEDDDKVDFKIKAKQYVKIYGQMAAIMPYEIVAWEKLFW
FLKFLIPKLKVKDPDTDAIDELLESVDLSSYGLQRVKLNHSISLDEEESGVDPQNPNPRG
ALGDGPQEDPLDEIVRTFNERWFQGWTATPEEQKVKFVNIAESIRQHPDFEAKYQNNPDP
HNRELAFEKMLKEVMLRRRKDELELYKMFAGDAAFKTAWMQSMQRMVDY