Protein Info for HP15_1578 in Marinobacter adhaerens HP15

Annotation: type I restriction-modification system, methyltransferase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 807 PF12161: HsdM_N" amino acids 9 to 149 (141 residues), 82.6 bits, see alignment E=6.8e-27 PF02384: N6_Mtase" amino acids 177 to 482 (306 residues), 202.5 bits, see alignment E=1.6e-63

Best Hits

KEGG orthology group: K03427, type I restriction enzyme M protein [EC: 2.1.1.72] (inferred from 85% identity to gpb:HDN1F_11600)

Predicted SEED Role

"Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72)" in subsystem Restriction-Modification System (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PM14 at UniProt or InterPro

Protein Sequence (807 amino acids)

>HP15_1578 type I restriction-modification system, methyltransferase subunit (Marinobacter adhaerens HP15)
MDHSAHNKLVSFIWNIADDCLRDVYVRGKYRDVILPMVVLRRLDTLLMPTKEAVLEEVRF
QKEEMDATELDPAPLKAASGYVFYNVSKWTLTSLYNTATNNRQILLANFEEYLKGFSPNV
QEIIECFELKSKIQHMAHKDVLLDVVEKFVSPKINLTPKDALDPDGYKLPGLSNLGMGYV
FEELIRKFNEENNEEAGEHFTPREVIELMTHLVFDPIKDDLPLTLTVYDPACGSGGMLTE
SQNFIEEKYPSDNRDIYLYGKEINDETYAICKSDMMIKGNNPENIKVGSTLSTDEFASDR
FDFMLSNPPYGKSWASEQKHIKDGSDVIDPRFKIQLKDYWGNEEDCDATPRSSDGQLLFL
MEMVSKMKDPATGSKGSRIASVHNGSSLFTGDAGGGESNIRRYLIENDWLEAIVQLPNNL
FYNTGITTYIWVLNNNKPANRRGKVQLIDASLLYRKLRKNLGNKNCEFAPDHIEQITRTY
LDCTAIERELDANNDPVGIASQVFRNEDFGYHKVTIERPDRRKAQFSEERIAGLRFDKQI
SEVMEHLYAEHGDKVYDSTGHGKDNKQSFLKSIEKPVMAWCDDNDISLNTKAKTKLLDVK
RWASLKAIYETARELMAAIGQDEFDDFNQFKKQVDTELKARKLKLSATEKNAILNAISWY
DETAEKVVKKVVKLNGDKLDELLHRYDCSAEQLPDYGLYPTGKANEYITFESSSDLRDSE
SIALLKDGEKQGIHGYFLAEVKPHVEEAWINLDSTKIGYEISFNKYFYRHKPLRSLEEVA
QDIISLEQKAEGLIAQILGVDVEQVQG