Protein Info for HP15_1568 in Marinobacter adhaerens HP15

Annotation: excinuclease ABC subunit C

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 620 TIGR00194: excinuclease ABC subunit C" amino acids 18 to 598 (581 residues), 652.2 bits, see alignment E=4e-200 PF01541: GIY-YIG" amino acids 28 to 103 (76 residues), 40.9 bits, see alignment E=7.3e-14 PF02151: UVR" amino acids 218 to 248 (31 residues), 39.6 bits, see alignment (E = 1.1e-13) PF22920: UvrC_RNaseH" amino acids 262 to 378 (117 residues), 121.8 bits, see alignment E=5e-39 PF08459: UvrC_RNaseH_dom" amino acids 396 to 551 (156 residues), 190.4 bits, see alignment E=7.1e-60 PF14520: HHH_5" amino acids 566 to 619 (54 residues), 36 bits, see alignment 2.8e-12 PF12826: HHH_2" amino acids 569 to 619 (51 residues), 27.6 bits, see alignment 9.2e-10

Best Hits

Swiss-Prot: 59% identical to UVRC_PSEAB: UvrABC system protein C (uvrC) from Pseudomonas aeruginosa (strain UCBPP-PA14)

KEGG orthology group: K03703, excinuclease ABC subunit C (inferred from 90% identity to maq:Maqu_1192)

MetaCyc: 54% identical to UvrABC excision nuclease subunit C (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit C" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PLC4 at UniProt or InterPro

Protein Sequence (620 amino acids)

>HP15_1568 excinuclease ABC subunit C (Marinobacter adhaerens HP15)
MPTRSDPESTHIGEFDSKSFLKQLTERPGVYRMYDEGGSVLYVGKARNLKKRVGSYFRKT
GLAPKTEALVGKIASIEVTITGSETEALLLEQNLIKSLRPPYNILLRDDKSYPYIYLSSH
SDYPSLTFRRGRTKKGGGTWFGPFPSSGAVKESLNVLQKIFRIRNCSESFFRNRTRPCLQ
YQINRCTAPCVEYITPEEYQQDIRHATMFLEGKNPAILHDLMNAMEAASKNLEFEKAAAY
RDQINHLRHVQEQQSVDGEGGDADVIAIAQDAGIVCIVVIIVRGGRVLGTKDYFPRYSIE
QTEGELLSAFLGQYYFGGNTRREIPRDILVPVEVEGQELLAQALSESANRETRIRGNVRG
ERRRWLELAMTNARQTLLTHLASKETVYRRLLALRDLLELSETPSRMECFDISHSHGENT
VASCVVFDENGPLKSDYRLYNIEGVTAGDDYAAMRQVLSRRYKRMVAGEGKRPDLVFIDG
GKGQLNIAREVFDELEISDIPLIGVAKGVTRRAGMEQLIDAMTGDVFRVPADSPALHLIQ
HIRDESHRFAITGHRARRDKKRRQSTLEGIEGVGPKKRRDLIRYFGGIQELRKAGVDEMT
KVQGISKSLAETIYAALHDE