Protein Info for PGA1_c16200 in Phaeobacter inhibens DSM 17395

Annotation: molybdopterin dehydrogenase, FAD-binding

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00941: FAD_binding_5
  • amino acids 2 to 170 (169 residues), 142.8 bits, E=9.5e-46
• PF03450: CO_deh_flav_C
  • amino acids 179 to 276 (98 residues), 84.3 bits, E=6e-28

Best Hits

KEGG orthology group: None (inferred from 70% identity to sil:SPOA0412)

Predicted SEED Role

"Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (10/11 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• guanosine nucleotides degradation III (4/4 steps found)
• inosine 5'-phosphate degradation (4/4 steps found)
• ureide biosynthesis (6/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Sequence Analysis Tools

See I7EZE4 at UniProt or InterPro

Protein Sequence (288 amino acids)

>PGA1_c16200 molybdopterin dehydrogenase, FAD-binding (Phaeobacter inhibens DSM 17395)
MEYHRPSSFAEAAELAASAKGVTRVLAGGTDVLVQMRADIVTPDTLIDIKSIEGARDIRQ
EDDGSWTIGAAVAGAEMSEHPALCAAWPGVVEAMDLIGSTQVQGRATLVGNLCNASPAAD
SVPALVAANATVSITGPKGHRRAAAVDIPSAPGKTTLTPGELITAVHLPAAQPGQGDAYL
RFIPRTEMDIAVVGCGVWLRLEGDTIAEARVALGAVAPTVLRVQACADALVGATLDTAAL
ERLAIAASDACAPITDKRGTIAFRTQVAGVMARRAAEIAYTRAKGDTV