Protein Info for PGA1_c15710 in Phaeobacter inhibens DSM 17395

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 31 to 143 (113 residues), 134.5 bits, E=4.2e-43
• PF02770: Acyl-CoA_dh_M
  • amino acids 147 to 240 (94 residues), 80.2 bits, E=2.1e-26
• PF00441: Acyl-CoA_dh_1
  • amino acids 253 to 398 (146 residues), 91.4 bits, E=1.3e-29

Best Hits

Swiss-Prot: 65% identical to GCDH_CAEEL: Probable glutaryl-CoA dehydrogenase, mitochondrial (F54D5.7) from Caenorhabditis elegans

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 92% identity to sit:TM1040_1255)

MetaCyc: 75% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (5/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (4/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (4/17 steps found)
• toluene degradation VI (anaerobic) (4/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Sequence Analysis Tools

See I7E0R6 at UniProt or InterPro

Protein Sequence (406 amino acids)

>PGA1_c15710 acyl-CoA dehydrogenase (Phaeobacter inhibens DSM 17395)
MTDRPALRAKDAPDLGQFNWDDPLRLDDQLSEDERMIAASARSYAQEKLQPRVLNAYENE
ETDPEIFREMGEMGLLGTTIPEQYGGLGAGYVSYGLVAREVERVDSGYRSMMSVQSSLVM
YPIYAYGSEEQRQKYLPKLSSGEWIGCFGLTEPDAGSDPAGMKTRAEKTDGGYRLTGSKM
WISNAPIADVFVVWAKSEAHGGKIRGFVLEKGMKGLSAPKIANKASLRASITGEIVMDGV
EVGDDALLPHVEGLKGPFGCLNRARYGISWGAMGAAEACWHAARQYGLDRKQFGRPLANT
QLFQLKLANMQTEITLGLQASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDMH
GGNGISLEFGVIRHMVNLETVNTYEGTHDVHALILGRAQTGLQAFF