Protein Info for Psest_0152 in Pseudomonas stutzeri RCH2

Annotation: Imidazoleglycerol-phosphate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00475: IGPD
  • amino acids 34 to 176 (143 residues), 210.9 bits, E=4.2e-67

Best Hits

Swiss-Prot: 98% identical to HIS7_PSEU5: Imidazoleglycerol-phosphate dehydratase (hisB) from Pseudomonas stutzeri (strain A1501)

KEGG orthology group: K01693, imidazoleglycerol-phosphate dehydratase [EC: 4.2.1.19] (inferred from 98% identity to psa:PST_4090)

Predicted SEED Role

"Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)" in subsystem Histidine Biosynthesis (EC 4.2.1.19)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.19

Sequence Analysis Tools

See L0GHH2 at UniProt or InterPro

Protein Sequence (197 amino acids)

>Psest_0152 Imidazoleglycerol-phosphate dehydratase (Pseudomonas stutzeri RCH2)
MSERTAYVERNTLETQVKVTINLDGTGKARFAIGVPFLEHMLDQIARHGLIDLDIECNGD
LHIDDHHTVEDVGITLGQAFIKAIGDKKGMTRYGHSYVPLDEALSRVVIDFSGRPGLTMN
VPYTRAVVGKFDVDLFQEFFQGFVNHALVTLHIDNLRGINTHHQIETVFKAFGRALRMAV
ELDPRMAGQMPSTKGCL