Protein Info for PGA1_c15240 in Phaeobacter inhibens DSM 17395

Annotation: two-component system histidine kinase / response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 771 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 45 to 65 (21 residues), see Phobius details PF00512: HisKA" amino acids 399 to 461 (63 residues), 34.8 bits, see alignment E=3.5e-12 PF02518: HATPase_c" amino acids 505 to 626 (122 residues), 89.8 bits, see alignment E=4e-29 PF00072: Response_reg" amino acids 655 to 766 (112 residues), 59.1 bits, see alignment E=1.2e-19

Best Hits

KEGG orthology group: K13587, two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC: 2.7.13.3] (inferred from 75% identity to sit:TM1040_1228)

Predicted SEED Role

"sensory box histidine kinase/response regulator"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E0I4 at UniProt or InterPro

Protein Sequence (771 amino acids)

>PGA1_c15240 two-component system histidine kinase / response regulator (Phaeobacter inhibens DSM 17395)
MNGRHASPVPQLRVYTPEHARLAAVLLLSGMVITAPWLFQTPEWITRGLVAVGLTLIAVA
LMMLVQARTRLRARSMAAALLTGFIDKDATATFVCDDDGMIHASNGAALKRFADADTETL
AGTLRSILANPSAVLFRLQSRARVDGAAREDIVTRRGHVRLAVHQMQGGSFLWRVEEITD
RPTTSRGADAVPIPMLTVGRTGAVLFMNEAARSLIGERVKSTDRLFTSLPVLSGQINTMS
TKSGLIEVLVCEKNRSQGRSELYFLQLADNETSVGQASLESLPVPFVKVDPKGTLLSANK
LGMHLLGISSCGNLNIGQLMDGLGRPMSDWLRDTADGQASHKSEFLRLTRRDKEVFVQVT
LTRVIEEGETVLIAVLNDATELKTLEAQFVQSQKMQAIGQLAGGVAHDFNNLLTAISGHC
DLLLLRHDQGDQDFGDLIQIHENANRAAALVSQLLAFSRKQTLQPEVLDVRDTLSDLTHL
LNRLVGEKVTLTLSHDPVMRSIRADKRQLEQVLMNLVVNARDAMPQGGEIRIETEAVVLD
QPLERNRAVVPAGDWVTVKVSDEGVGISPDKLQKVFEPFYTTKRTGEGTGLGLSTAYGII
KQTGGYIFVDSIKDQGTQFTLFFPVNTQVEPEAAAAITVDATAKPVAAQHGEGVVLLVED
EAPVRAFASRALRMRGYTVLEAESAEDALRTLEDPGLTVDVFVTDVVMPGMDGPSWVREA
LKTRPDTRVVFVSGYAEGAFGEAEPSVPNSVFLPKPFSLNQLTETVHEQLH