Protein Info for PGA1_c15160 in Phaeobacter inhibens DSM 17395
Annotation: glucose-6-phosphate 1-dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 56% identical to G6PD_RHIME: Glucose-6-phosphate 1-dehydrogenase (zwf) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K00036, glucose-6-phosphate 1-dehydrogenase [EC: 1.1.1.49] (inferred from 76% identity to sil:SPO2048)Predicted SEED Role
"Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)" in subsystem Entner-Doudoroff Pathway or Pentose phosphate pathway (EC 1.1.1.49)
MetaCyc Pathways
- aspartate superpathway (23/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
- L-lysine biosynthesis I (9/9 steps found)
- superpathway of glucose and xylose degradation (14/17 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
- Entner-Doudoroff pathway I (8/9 steps found)
- pentose phosphate pathway (7/8 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
- L-lysine biosynthesis VI (6/7 steps found)
- L-lysine biosynthesis II (7/9 steps found)
- heterolactic fermentation (13/18 steps found)
- pentose phosphate pathway (oxidative branch) I (2/3 steps found)
- cytosolic NADPH production (yeast) (3/5 steps found)
- formaldehyde oxidation I (3/6 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (4/8 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Glutathione metabolism
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.49
Use Curated BLAST to search for 1.1.1.49
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See I7EWN8 at UniProt or InterPro
Protein Sequence (495 amino acids)
>PGA1_c15160 glucose-6-phosphate 1-dehydrogenase (Phaeobacter inhibens DSM 17395) MVSRVIPVQAFDLVIFGGTGDLAQRKILPALFRRHCAGQLPQDARIVGAARRALGSDGYR DLIRDALQNELSGAEIAARGEELERFLARLEYLAIDAEARDGWAALKQMLGLPTSDRVRV FYFSVGPALFAPLAEQIWTHQLADDQTRIVVEKPFGHDLASAKALNRTLAGHFDESQIYR IDHYLGKETVQNLMAIRFGNMLFEPLWNSQYVDHIQITVAESVGVDGRASYYDKSGAMRD MMQNHLMQLLCLIAMEPPAKFDPDAVRDEKLKVIRALEPVEPHHIVRGQYALAEDGEGGD EDQSYRETVGDPRSSTESYVALKAHISNWRWAGTPFYLRTGKRLVARSSVINVFFKDAPH SIFGADAGRHANLLTIRLQPDEGITLKVTIKEPGPGGMRLIDVPLDMSFAQALGADIDDA PDAYERLITDVIRGNQTLFMRGDEVEAAWAWTDPIIAGWTSRGDVPKPYDSGSTGPGDAD LLMRRDQRDWQGINP