Protein Info for HP15_1414 in Marinobacter adhaerens HP15

Annotation: histone deacetylase superfamily protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 368 PF00850: Hist_deacetyl" amino acids 49 to 335 (287 residues), 311 bits, see alignment E=4.6e-97

Best Hits

KEGG orthology group: None (inferred from 64% identity to aeh:Mlg_2048)

Predicted SEED Role

"Acetylspermidine deacetylase (EC 3.5.1.48); Deacetylases, including yeast histone deacetylase and acetoin utilization protein" (EC 3.5.1.48)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.48

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJJ2 at UniProt or InterPro

Protein Sequence (368 amino acids)

>HP15_1414 histone deacetylase superfamily protein (Marinobacter adhaerens HP15)
MIGDRSVNVFYDEIMLGHNPEVDLPFMPSRVEKRVRSILQGLDFKWSYPEHPGRISAIKE
YLDENPVAGTQFKSGAAAATYDQLARVHTTSYLDHIFSLDGKRAWLDKDTTAVSPDSIKA
ATAAAGNAIAAVESVVKGECNSAFALIRPPGHHAEPVRARGFCLLNNVAIAAAHAQAKLG
CEKILIIDWDAHHGNGTQDIFWADPDVLFFDTHCAAPFYPGSGHLEEIGDGLGEGYTINV
PLPETAGDVAFEKVFREILMPAADYFQPDLVLVSAGFDPHRNDMALNLTYDGFKVITGIV
QAIADKHCEGRLALVLEGGYSLSSLSKGVHAVLEVLAGGEVPEVHEIGVPEAEEAAEFHR
SAFSDDQE