Protein Info for PGA1_c14260 in Phaeobacter inhibens DSM 17395

Annotation: peptidase M50

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 40 to 58 (19 residues), see Phobius details amino acids 120 to 143 (24 residues), see Phobius details amino acids 379 to 399 (21 residues), see Phobius details amino acids 424 to 444 (21 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 14 to 447 (434 residues), 259.3 bits, see alignment E=3.1e-81 PF02163: Peptidase_M50" amino acids 20 to 437 (418 residues), 218.9 bits, see alignment E=1.1e-68 PF17820: PDZ_6" amino acids 225 to 277 (53 residues), 41.2 bits, see alignment 2.4e-14

Best Hits

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 67% identity to rde:RD1_2591)

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E084 at UniProt or InterPro

Protein Sequence (449 amino acids)

>PGA1_c14260 peptidase M50 (Phaeobacter inhibens DSM 17395)
MDFVSFLPQLGGYLYVIASFVVALSVIVAVHEYGHYIVGRWSGIHAEVFSLGFGPVLFSR
VDKRGTRWQVALLPFGGYVKFLGDADAASGKDADAMADAATDPVALRRTMHGAPLWARSA
TVAAGPVFNFIMSALIFAGVFMLQGTMRDPLTVERLVPLPGLQTGLREGDALLKIEGVDV
PSLEDGVAFTAFRDAVPEQQPLTYTVLRDEREVEVEGPYPWPPHVRGVAPRSAAADIDLQ
PGDVITAVDGAPIFAFDQLKRAVESAEGKVLLLDVWRAGEEFEMALAPRRVDEPQPEGGF
ATRWRMGIAGGLAFDPATETVGIGEALGGGAAQVWGVVEMSLSGLGHMITGAISTCNLSG
PIGIAETSGAMASQGAESFIRFIAVLSTAVGLLNLFPIPALDGGHLVFYAYEAVTGKPPN
DTVMRILMSVGIAAILSLMMFALFNDIFC