Protein Info for PGA1_c14010 in Phaeobacter inhibens DSM 17395

Updated annotation (from data): Xylulose kinase (EC 2.7.1.17)
Rationale: Specifically important for utilizing D-Xylose. Automated validation from mutant phenotype: the predicted function (XYLULOKIN-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Original annotation: xylulose kinase XylB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00370: FGGY_N
  • amino acids 1 to 240 (240 residues), 219 bits, E=7.8e-69
• TIGR01312: xylulokinase
  • amino acids 3 to 467 (465 residues), 534.7 bits, E=9.4e-165
• PF02782: FGGY_C
  • amino acids 250 to 434 (185 residues), 117.7 bits, E=5.9e-38

Best Hits

KEGG orthology group: K00854, xylulokinase [EC: 2.7.1.17] (inferred from 60% identity to sit:TM1040_0028)

Predicted SEED Role

"Xylulose kinase (EC 2.7.1.17)" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization or Xylose utilization (EC 2.7.1.17)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (14/17 steps found)
• D-xylose degradation I (2/2 steps found)
• D-arabinitol degradation I (1/2 steps found)
• xylitol degradation I (1/2 steps found)
• superpathway of pentose and pentitol degradation (11/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.17

Sequence Analysis Tools

See I7E053 at UniProt or InterPro

Protein Sequence (478 amino acids)

>PGA1_c14010 Xylulose kinase (EC 2.7.1.17) (Phaeobacter inhibens DSM 17395)
MYLGIDLGTSGLRALMTDAAGKPVASAEAQYDVQTPHPGWSEQDPGDWITALDQAMAQLQ
GSPGYSDICGIAVAGHMHGAVLLDGSDQVLRPCILWNDTRSAAEAAELDAAEKVRDLSGN
IVFPGFTAPKLLWVQRHEPEIFANTAKVLLPAAYLNLHLTGRHVADMSDSAGTSWLDVGA
RDWSEWLLEAGHMRRDQMPDLVEGSAAAGTLRPELAVRWGLTGPVTIAGGAGDNAAAACG
TGVMAPGQGFVSLGTSGVVLTARDGFRPDPATAVHTFCHAIPDRWYQMGVMLSATDCMNW
LGRITGQSPADLTAGLGEELQPPGPVTFMPYLSGERTPHNSASLRGGFQGLSIATTAEDL
ARAVMEGVCYGLRDCLEALRKTGAEIDSCLVIGGGSKSAYWVKLLATILDLPLQLPKDGE
FGAALGAARLARLAVTGDDPADVLTAPESAMTVAPDPLLRDGYEAGYAAFRRRGAELT