Protein Info for HP15_1346 in Marinobacter adhaerens HP15

Annotation: sulfate ABC transporter, inner membrane subunit CysW

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 276 transmembrane" amino acids 20 to 43 (24 residues), see Phobius details amino acids 62 to 87 (26 residues), see Phobius details amino acids 99 to 122 (24 residues), see Phobius details amino acids 141 to 159 (19 residues), see Phobius details amino acids 199 to 222 (24 residues), see Phobius details amino acids 246 to 269 (24 residues), see Phobius details TIGR02140: sulfate ABC transporter, permease protein CysW" amino acids 15 to 274 (260 residues), 404.4 bits, see alignment E=2.2e-125 TIGR00969: sulfate ABC transporter, permease protein" amino acids 18 to 272 (255 residues), 344.7 bits, see alignment E=3.8e-107 PF00528: BPD_transp_1" amino acids 79 to 269 (191 residues), 51.9 bits, see alignment E=4e-18

Best Hits

Swiss-Prot: 65% identical to CYSW_ECOL6: Sulfate transport system permease protein CysW (cysW) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02047, sulfate transport system permease protein (inferred from 77% identity to maq:Maqu_1371)

MetaCyc: 65% identical to sulfate/thiosulfate ABC transporter inner membrane subunit CysW (Escherichia coli K-12 substr. MG1655)
ABC-19-RXN [EC: 7.3.2.5]; ABC-7-RXN [EC: 7.3.2.5, 7.3.2.3]; 7.3.2.3 [EC: 7.3.2.5, 7.3.2.3]; TRANS-RXN0-478 [EC: 7.3.2.5, 7.3.2.3]; TRANS-RXN0-479 [EC: 7.3.2.5, 7.3.2.3]

Predicted SEED Role

"Sulfate transport system permease protein CysW" in subsystem Cysteine Biosynthesis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.3.2.3 or 7.3.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJC4 at UniProt or InterPro

Protein Sequence (276 amino acids)

>HP15_1346 sulfate ABC transporter, inner membrane subunit CysW (Marinobacter adhaerens HP15)
MAARKHRRVGDSPLVRRTLIGIAVGLTVLLLFMPLVLIFVQAFAEGWVGYVSNILNEYTL
HAIGLTLVVALLTVPLNMVFGVFLAWLVTRFRFPGRKLLTTLIDIPFAVSPVVAGLLFLL
LYGSNGWVGRWLGEYDIQLMFSWPGIVMVTVFVTCPFVARELIPLMQQQGREEEEAGVVL
GASGWQLFRRVTLPNIRWALLYGVILTNARAVGEFGAVSVVSGNIRGETNTLPLQVELLY
QDYNTVGAFAASSLLAGIALITLVVKAIVEWRQSRN