Protein Info for PGA1_c13430 in Phaeobacter inhibens DSM 17395

Annotation: C4-dicarboxylate transport sensor protein DctB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 589 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 292 to 311 (20 residues), see Phobius details PF00512: HisKA" amino acids 366 to 430 (65 residues), 34.5 bits, see alignment E=1.7e-12 PF02518: HATPase_c" amino acids 475 to 580 (106 residues), 66.6 bits, see alignment E=2.7e-22

Best Hits

KEGG orthology group: K10125, two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC: 2.7.13.3] (inferred from 85% identity to sit:TM1040_1462)

Predicted SEED Role

"C4-dicarboxylate transport sensor protein DctB"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7ELD9 at UniProt or InterPro

Protein Sequence (589 amino acids)

>PGA1_c13430 C4-dicarboxylate transport sensor protein DctB (Phaeobacter inhibens DSM 17395)
MTAARDATTSSEKPRSRTTSWRVRLALLVLMAVAAVTVWVTNRALTDRFTESTRNRAELR
LALYSGNLVSELGRHAIVPQLLARDQALISALQSNDFSLSTQRLISFVEEIGAASIMLMA
QDGRTVAATDRNRLGETHRNAAYFVDALRSKTTVFSAIRTEVGSYRFTYSRRIVDTSGIL
GVIVVEVDLQKFERAWAGISDAVMVSDSTGTILLATESRWRGLSEEDALQLQTPEGAIQR
AIRATTDWTALPADAYLQGEAVMRLESRIPFQGWRLTSFTTYASIRERVNTVLALEIMGF
AILLALAFYALSRRTALRMALFQRESAELRVLNARLQREIAERERMQETLAVAEQSLAQS
SKLAALGEMSAAVSHELNQPLAAMKTYLAGARLLLNRNRPEEALASFGRIDDLIERMGAI
TRQLKSYARKGGDAFSPVNMGDALASSLSMMEPQLRQRHVKIARILPEQPVYVMGDRMRI
EQVMVNLLRNALDATKSVADPEVEILLAAGETATLSVRDNGMGIKDFGSLFEPFYTTKQP
GDGVGLGLAISSGIVNDLGGRLTARNGQNGGAVFEMQLPILVDGIEAAE