Protein Info for HP15_1296 in Marinobacter adhaerens HP15
Annotation: valine-pyruvate transaminase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 51% identical to AVTA_ECOLI: Valine--pyruvate aminotransferase (avtA) from Escherichia coli (strain K12)
KEGG orthology group: K00835, valine--pyruvate aminotransferase [EC: 2.6.1.66] (inferred from 93% identity to maq:Maqu_0943)MetaCyc: 51% identical to valine--pyruvate aminotransferase (Escherichia coli K-12 substr. MG1655)
Valine--pyruvate transaminase. [EC: 2.6.1.66]; 2.6.1.- [EC: 2.6.1.66]
Predicted SEED Role
"Valine--pyruvate aminotransferase (EC 2.6.1.66)" in subsystem Alanine biosynthesis or Branched-Chain Amino Acid Biosynthesis or Pyruvate Alanine Serine Interconversions (EC 2.6.1.66)
MetaCyc Pathways
- superpathway of L-alanine biosynthesis (4/4 steps found)
- L-alanine biosynthesis I (2/2 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.66
Use Curated BLAST to search for 2.6.1.66
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E4PII5 at UniProt or InterPro
Protein Sequence (425 amino acids)
>HP15_1296 valine-pyruvate transaminase (Marinobacter adhaerens HP15) MKLSAFGRKFTADAGITSLMDDLGNAMASGDDMIMMGGGNPGHIPEIQQRVQEILADMSR NEGDVRRLVGIYDPPQGEKQFIASLAELLNREYGWGLKPENIALTNGSQAAFFMLFNMFG GDYGDGNRKHILLPLAPEYIGYADAGIEPGLFHAVQPDISFTDAHEFKYRVDFDAVEVTG ETGAICVSRPTNPTGNVVTDEELARLEELARQHDIPLIVDGAYGTPFPSLLFVDAAPTWN DQIILCLSLSKLGLPAARTGIVIAAEPVIKALSGINAIMNLATGSFGAMLAEPLVRSGEI LSLSRDVVCPFYKAKMERAVSAFREAMGEDSCRWYVHKPEGAMFLWLWFPDLPISSLELY QRLKSRGVLVVSGHYFFPGLPEDGWRHRHECLRVTYSQDDDRVAEGLRIIADEVKAVWRE AGREV