Protein Info for PGA1_c13030 in Phaeobacter inhibens DSM 17395

Annotation: putative tetracycline resistance protein, class C

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 404 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details amino acids 44 to 65 (22 residues), see Phobius details amino acids 77 to 96 (20 residues), see Phobius details amino acids 102 to 122 (21 residues), see Phobius details amino acids 134 to 155 (22 residues), see Phobius details amino acids 164 to 184 (21 residues), see Phobius details amino acids 205 to 228 (24 residues), see Phobius details amino acids 248 to 270 (23 residues), see Phobius details amino acids 282 to 327 (46 residues), see Phobius details amino acids 338 to 361 (24 residues), see Phobius details amino acids 371 to 393 (23 residues), see Phobius details PF07690: MFS_1" amino acids 12 to 355 (344 residues), 166.6 bits, see alignment E=1.1e-52 PF00083: Sugar_tr" amino acids 34 to 186 (153 residues), 57 bits, see alignment E=2.5e-19 PF05631: MFS_5" amino acids 54 to 160 (107 residues), 26.3 bits, see alignment E=5.4e-10

Best Hits

KEGG orthology group: K08151, MFS transporter, DHA1 family, tetracycline resistance protein (inferred from 45% identity to sil:SPOA0431)

Predicted SEED Role

"Tetracycline efflux protein TetA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EYM6 at UniProt or InterPro

Protein Sequence (404 amino acids)

>PGA1_c13030 putative tetracycline resistance protein, class C (Phaeobacter inhibens DSM 17395)
MKLTGPFLFILATLMIDAIGVGIVFPIMPDLMLRVGAQSTAEGALWSGIMMSAYAAAMFL
FGPIVGSLSDSYGRRPVLILALVTLTIDYVIMALAQTYWMLLIGRVIAGMAGATYITATA
YISDIAKPTERGAAFGMIGAAFGIGFVLGPALGGLASGLHISAPFWIAAGLSALNVVFGI
VILPESLKPENRRPFGKRDLNPFGTLIRAFVIPGLAIPLICIFVFEFANLVYPTLWSFWG
REVFGWDGFTIGVTLSAYGVLIAVVQAGILPQMTKRLGDYKTLIIAMVAAVIAMIGFGLA
SAIWVVVVFLPIAALSDMAPPLITAFAANRVGEDQQGVVQGVIASLSSVAAVVAPLVLTG
VFERFVGEAEWYLPGAPFLVAAVLVLALAPLVLRLRDHDNRSSN