Protein Info for PGA1_c13020 in Phaeobacter inhibens DSM 17395

Annotation: signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 476 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 187 to 209 (23 residues), see Phobius details PF00512: HisKA" amino acids 264 to 324 (61 residues), 33.5 bits, see alignment E=3.4e-12 PF02518: HATPase_c" amino acids 371 to 475 (105 residues), 76.6 bits, see alignment E=2.1e-25

Best Hits

Predicted SEED Role

"PROBABLE TRANSMEMBRANE SENSOR HISTIDINE KINASE TRANSCRIPTION REGULATOR PROTEIN( EC:2.7.3.- )"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DZV5 at UniProt or InterPro

Protein Sequence (476 amino acids)

>PGA1_c13020 signal transduction histidine kinase (Phaeobacter inhibens DSM 17395)
MSALRQAIALSLAFLVLLTLGGLLLDDVITEEFRAETEEALREEYQRISDRLTREGRFPE
EIVTAEVFSDSGVGYAVLRADGKVLGPVLRGAFDSQGFDILEAEALFQPKALETLDRIFD
LIDEDDEEELSDSGPAAEETAAGQLAFDVAFESEADLGWRIYSGAVLDGHLVVYAPGVSA
FGSDLTSVILVFVVILSLPALIIGLIFGIRAQRRLNRIGAGFDRIADGELDLRLAPKVIR
DDIDELAARIDGATERLQASIRQMSDFSANIAHDLRTPLTRLRLHLDQADEAEDQTAHRE
AAIAQMDDIIAIFGAIQRIARMQSQGRRDGFAAVDLGVVVEQVHEIYEAVAQDAGQSLSC
RITNAATIHADRSLIMQLLANLIENAIRHAGEGARIAIGLSGSRLVVTDDGPGIPEAERG
RVLDPLYRLDRSRNTAGAGLGLAMVKAIAELHEAELALMYSADERGLRIEVRFPQP