Protein Info for PGA1_c13010 in Phaeobacter inhibens DSM 17395

Annotation: two-component system response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 225 PF00072: Response_reg" amino acids 3 to 112 (110 residues), 81.3 bits, see alignment E=6.1e-27 PF00486: Trans_reg_C" amino acids 148 to 223 (76 residues), 87 bits, see alignment E=7.1e-29

Best Hits

Swiss-Prot: 45% identical to CUSR_ECO57: Transcriptional regulatory protein CusR (cusR) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 60% identity to mme:Marme_0369)

Predicted SEED Role

"DNA-binding heavy metal response regulator" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EL98 at UniProt or InterPro

Protein Sequence (225 amino acids)

>PGA1_c13010 two-component system response regulator (Phaeobacter inhibens DSM 17395)
MRILLLEDDPEIGTWTVKGLTAAGHVVDWIENGREALLAATTRDYDVLVFDRMTPDLDGL
SALKTLRSARITTPLILLTALGAVEDRVEGLEAGADDYLSKPFAMTELLARITALGRRGR
AEAAETATRLSHRGLDLDLLSQTCACNGTTVLLNPKEFRLLEVLMRSKGRIQTRAMLLER
VWDINFDPSTSVVETHMSRLRNKIEKPFGLEFIKTVRGSGYMFID