Protein Info for HP15_1254 in Marinobacter adhaerens HP15

Annotation: cyclic nucleotide-binding domain (cNMP-BD) protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 638 PF00027: cNMP_binding" amino acids 45 to 133 (89 residues), 31.1 bits, see alignment E=3.8e-11 PF00571: CBS" amino acids 179 to 229 (51 residues), 38.9 bits, see alignment 1.7e-13 amino acids 240 to 291 (52 residues), 46.7 bits, see alignment 6.7e-16 PF03445: DUF294" amino acids 319 to 457 (139 residues), 142.4 bits, see alignment E=1.8e-45 PF10335: DUF294_C" amino acids 495 to 634 (140 residues), 150.2 bits, see alignment E=7.3e-48

Best Hits

KEGG orthology group: K07182, CBS domain-containing protein (inferred from 88% identity to maq:Maqu_0903)

Predicted SEED Role

"Predicted signal-transduction protein containing cAMP-binding and CBS domains" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHQ3 at UniProt or InterPro

Protein Sequence (638 amino acids)

>HP15_1254 cyclic nucleotide-binding domain (cNMP-BD) protein (Marinobacter adhaerens HP15)
MASAHQENDRPQNIRAIMTFLREHAPFSSMDDSHLAHFAENASIQFYADGDIVLSPDQDV
VKRFYVVKQGRIRGERHNDKEDRTETTFEISQGECFPLAAMIGERPTRTLHRADGDTFCL
SIGQTAFVTLFAESEPFRDFCLRGVSSLLDQVNRRIQSSAMASIGSSTSLDTPLERYALR
NPIVCSPDLPVRKAVARMHENNVGSIIVTDENRIPTGIFTLRDLRTMIAEGTGPLDTPIQ
QVMTKNPCCLPSHADAFEAAMLMAEHHFAHLCVIDDDRKLIGVVSERDLFSLQRVDLVNL
ARTIGTATHLRTLVSLRTDVSRLVDAMLAHGADSGQVVKIITTLNDVTVRRVLELNIKKN
DPGIPFTWLTFGSEGRQEQTLLTDQDNGILFQTPEGMTAEQVREKLLPFARKVNDELAEC
GFTLCKGNIMASNPKLCLSDKEWDDWFIRFIDASTPQNLVYSSIFLDMRAIYGPTEPLND
LLDKILTRIRKNALFQKMLAGNAFQRKPPLTMFRNFRYISEGNKHSLDLKRQGLAPFVEA
VRVFALANGVETANTLERMDELAKKGVFDPKDANAWKEGYSLIQAIRMRAHQEMLAKGEE
LTNYIDPDDLNPLDRRILRESFRQAQRLQQKLEVTYQL