Protein Info for HP15_1249 in Marinobacter adhaerens HP15

Annotation: two-component system sensor protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1172 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 37 to 56 (20 residues), see Phobius details amino acids 68 to 87 (20 residues), see Phobius details amino acids 115 to 134 (20 residues), see Phobius details amino acids 164 to 181 (18 residues), see Phobius details amino acids 202 to 222 (21 residues), see Phobius details amino acids 246 to 264 (19 residues), see Phobius details amino acids 285 to 307 (23 residues), see Phobius details amino acids 331 to 361 (31 residues), see Phobius details amino acids 382 to 405 (24 residues), see Phobius details amino acids 416 to 438 (23 residues), see Phobius details amino acids 445 to 467 (23 residues), see Phobius details amino acids 503 to 521 (19 residues), see Phobius details PF12860: PAS_7" amino acids 655 to 769 (115 residues), 125.7 bits, see alignment E=2e-40 PF00512: HisKA" amino acids 810 to 874 (65 residues), 46.9 bits, see alignment 4.6e-16 PF02518: HATPase_c" amino acids 919 to 1025 (107 residues), 85.1 bits, see alignment E=9.2e-28 PF00072: Response_reg" amino acids 1054 to 1163 (110 residues), 55.1 bits, see alignment E=1.6e-18

Best Hits

KEGG orthology group: None (inferred from 88% identity to maq:Maqu_0898)

Predicted SEED Role

"Serine phosphatase RsbU, regulator of sigma subunit" in subsystem SigmaB stress responce regulation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHP8 at UniProt or InterPro

Protein Sequence (1172 amino acids)

>HP15_1249 two-component system sensor protein (Marinobacter adhaerens HP15)
MISAWLLVLISITYISILFVIAWAGDKHPGLYRRRLARTHIYALSLAVYFTSWTFYGAVG
RATQEGLGFLPIYLGPLLVFVFGAPLLRRIIYISKRNNSTSIADFIASRYGKSQLLAAMI
ATFALIGSVPYIALQLKAIAMGFNVLSATGTGYEELSTAAWSDSAWYITLALAVFTVLFG
TRHLESTEHHRGMIQAVAFESLIKLVAFVAVGLFVGYGLYGGFGDLFERARDADLIGTLT
TDGIEAPAFITQTLIAMLAIICLPRQFHVMVVENTDHRDFEIARWAMPIYLIVASAFVLP
IAAAGLLSPEASAGNPDILILQLPIMAGEEWLAILAFLGGGSAAAAMVIVCSVAIATMVS
NEIIMPALLKFFRPGMNRRTDLSYLLLSIRRVAIFVVLLTAYGFYRMAGEDYSLTAFGLL
SFAAAAQFGPALVGGIIWRRGNYMGAVWGLGLGFLMWCYTLLLPALATTGWVNDTLIEQG
IWGLNWTRPTALFGSELDQTSHGIIWSLGINTLVYIVLSMLTRQRVREKIQIASFFHDPQ
PKAETAQHQSWQGEILTSDLRALTDRFMGEERSETIFRNYERRNAIRLHPHRPASAHLMK
YIERQLASVIGASTARVVLESTLTGRDMQIEDVVSIVDEASQAMTFSRELLQSAIENISL
GVSVVNHQQQLVVWNHRYLELFTYPKGFVRVGRPVEDLMRYNLTNANLSARRIDEIVVDR
CTSMREGRPMSYERQRPDGTVLRIDGSPIPGGGYVTTFQDITAMRRTEQALKETNIYLEQ
RVKERTQELQVINEQMLKAKSVAEQANQSKTRFLASASHDLLQPLNAARLFTSALAGKAD
DGEMKDLVDHIDSSLGAAEEIISTLLDISKLDAGALEPDIGVFPVNEIMRHLATDFSAIA
KDQNLELHVVPSTAWIRSDSKLLRRVVQNFLSNAIRYTPEGKILLGCRRLKGYIRIEVWD
TGPGIPEDQLAHIFEEFRRFQHGRDKKGLGLGLAIVDRISGMLNHPVSVHSVQGRGSVFG
ITVPTAAPEQNETTSAKPASGSRRVSNLGGLHFLCIDNDPAILQGMVALLGNWKCDVTAA
ESLEDAMEKLEGNRPDIILADYQLDDNKNGLDAMDSIRGALNANIPGILITGYMAPEVRE
DAINRGYQILYKPVKPAALRALVNKLLKQKRS