Protein Info for PGA1_c12890 in Phaeobacter inhibens DSM 17395

Annotation: putative thiamine biosynthesis protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF09084: NMT1" amino acids 34 to 253 (220 residues), 123.1 bits, see alignment E=7.8e-40

Best Hits

KEGG orthology group: K02051, sulfonate/nitrate/taurine transport system substrate-binding protein (inferred from 88% identity to sit:TM1040_1493)

Predicted SEED Role

"Pyrimidine ABC transporter, substrate-binding component" in subsystem Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DPL5 at UniProt or InterPro

Protein Sequence (328 amino acids)

>PGA1_c12890 putative thiamine biosynthesis protein (Phaeobacter inhibens DSM 17395)
MKTLLTAAAMALGAASVAQAADEVKLQLKWVTQAQFAGYYVALDQGFYEAEDLDVTILPG
GPDIAPTQVIAGGGADVTVEWMPAALAAREKGLPLVNIAQPYKSSGMMLTCWKDTGIAAP
EDLANRTLGVWFFGNEFPFMSWMSQLGISTEGKGEKGVEVLKQGFNVDPLLQRQADCIST
MTYNEYWQVIDAGVAPDELISFKYEDQGVATLEDGLYVLEENLNDPAFVDKMQRFVRASM
KGWKWAEENPDNAAEIVLDNDASGAQTEEHQKRMMSEVAKLTAGSNGALSEADYQRTVKT
LLDGGSSPVITKEPEGAWTHVITDAALN