Protein Info for PGA1_c12460 in Phaeobacter inhibens DSM 17395

Annotation: Mn-dependent hydrolase SoxB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 565 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR04486: thiosulfohydrolase SoxB" amino acids 3 to 564 (562 residues), 835.6 bits, see alignment E=7.6e-256 PF00149: Metallophos" amino acids 51 to 307 (257 residues), 28.4 bits, see alignment E=2.2e-10 PF02872: 5_nucleotid_C" amino acids 382 to 535 (154 residues), 66.4 bits, see alignment E=3.4e-22

Best Hits

KEGG orthology group: None (inferred from 85% identity to rde:RD1_1515)

MetaCyc: 74% identical to SoxB (Paracoccus pantotrophus)
RXN-11952 [EC: 3.1.6.20]; 3.1.6.20 [EC: 3.1.6.20]; SOXA-FDENIT-RXN [EC: 3.1.6.20]

Predicted SEED Role

"Sulfur oxidation protein SoxB" in subsystem Sulfur oxidation

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.6.20

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EL48 at UniProt or InterPro

Protein Sequence (565 amino acids)

>PGA1_c12460 Mn-dependent hydrolase SoxB (Phaeobacter inhibens DSM 17395)
MISRRDFLQVSMAASALVGASGFGNWGRLAAQQRLTQDQLLQFDTYGNISLIHVTDIHAQ
LKPIYFREPSINLGVGDNKGHVPHITGADFRKAYGIADGSPSAYALTYNDFASLAQGYGR
VGGLDRVATIINAIRADRPDALLLDGGDTWHGSYTCHHTEGQDMVNVMNALKPDAMTFHW
EFTLGSDRVNEIVEGLPFAALGQNIFDAEWDEPAELFKPYKFFDRGGAKVAVIGQAFPYM
PIANPGWMFPEYSFGIRDEHMQDMVDEVRAAGADVVVVLSHNGFDVDKKMAGVVSGIDVI
LSGHTHDALPEPVLVGQTHIVASGSNGKFVSRVDLDVRDSQLMGLRHKLIPVFSDVIAPD
PVITQLIDDQRAPYEADLAEVIGQTDELLYRRGNFNGTWDDLICDALLSEREADIALSPG
VRWGPSLLPGDDITREDIWNVTSMSYGAAYRNEMTGEFLKVVMEDVADNIFNPDPYYQQG
GDMVRVGGMGYHIDITKPQGERISNMTLLKTGEAIDPAKTYIVAGWASVNEGTEGPQIWD
VVENHIRKMGTVTLSPNTSVQVSGA