Protein Info for PGA1_c12080 in Phaeobacter inhibens DSM 17395

Annotation: putative acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF12418: AcylCoA_DH_N
  • amino acids 3 to 33 (31 residues), 28.8 bits, see alignment (E = 2.5e-10)
• PF02771: Acyl-CoA_dh_N
  • amino acids 79 to 156 (78 residues), 56.3 bits, E=1e-18
• PF02770: Acyl-CoA_dh_M
  • amino acids 161 to 269 (109 residues), 54.5 bits, E=2.7e-18
• PF00441: Acyl-CoA_dh_1
  • amino acids 281 to 445 (165 residues), 66.1 bits, E=1.1e-21
• PF12806: Acyl-CoA_dh_C
  • amino acids 461 to 588 (128 residues), 131.4 bits, E=5.3e-42

Best Hits

KEGG orthology group: K00257, [EC: 1.3.99.-] (inferred from 88% identity to sit:TM1040_1557)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

• oleate β-oxidation (30/35 steps found)
• fatty acid salvage (6/6 steps found)
• adipate degradation (5/5 steps found)
• 2-methyl-branched fatty acid β-oxidation (10/14 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Benzoate degradation via CoA ligation
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Brassinosteroid biosynthesis
• Caprolactam degradation
• Fatty acid metabolism
• Geraniol degradation
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7, 1.3.99.-

Use Curated BLAST to search for 1.3.8.7 or 1.3.99.-

Sequence Analysis Tools

See I7EYE4 at UniProt or InterPro

Protein Sequence (593 amino acids)

>PGA1_c12080 putative acyl-CoA dehydrogenase (Phaeobacter inhibens DSM 17395)
MPSYTAPIKDTQFILHNVLKISQSGIPGYDELDADFTNAVLEEAGKISSEVLHPLNTVGD
IEGCRLENGVVYTPTGFKAAFEQVKEGGWTGLDMPEQYGGQNMPYVMGTAVGEMFSAANQ
AFTMYQGLTHGAASAILAHGTDAQKDTYLPKMVSCEWTGTMNLTEPHCGTDLGLMRTKAE
PQDDGSYKITGQKIFISSGDHDMADNIIHLVLAKIPGGPDGIKGVSLFIVPKFIVKDGGS
LGDRNGVSVGKIEEKMGIHGNSTCVMNYDSATGYLLGTEHKGMRAMFTMMNEARLGVGMQ
GLAQAEAAYQNALEYAKDRLQGRDVTGVKNPDGPADPLIVHPDIRRNLMDQKSFAEGARA
FILWGAKMIDQAHRAEDKDADGLISLLTPVIKGFLTDQGYDMTVQAQQIYGGHGYIEEWG
MSQYTRDARIAMIYEGANGVQALDLVGRKLAQDGGKHVMAFFEMVKNFCKENGDISEGYS
KEFIEPLKAASKDLQAAGMYFMQNGMTNPNNALSGSYDFMHMFGHVCLGLMWAEMAKAAQ
AELDAGSSDAAFYETKIATGRYYMARQLPATALHLSRIQTGGDTVMALAADQF