Protein Info for PGA1_c11940 in Phaeobacter inhibens DSM 17395

Annotation: thymidine phosphorylase DeoA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 TIGR02644: pyrimidine-nucleoside phosphorylase" amino acids 5 to 420 (416 residues), 452.4 bits, see alignment E=7e-140 PF02885: Glycos_trans_3N" amino acids 5 to 66 (62 residues), 53.1 bits, see alignment E=3.3e-18 PF00591: Glycos_transf_3" amino acids 76 to 305 (230 residues), 137.7 bits, see alignment E=8.3e-44 PF07831: PYNP_C" amino acids 347 to 420 (74 residues), 57.8 bits, see alignment E=1.1e-19

Best Hits

Swiss-Prot: 51% identical to TYPH_PECAS: Thymidine phosphorylase (deoA) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K00758, thymidine phosphorylase [EC: 2.4.2.4] (inferred from 71% identity to sit:TM1040_1571)

Predicted SEED Role

"Thymidine phosphorylase (EC 2.4.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 2.4.2.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EVW0 at UniProt or InterPro

Protein Sequence (436 amino acids)

>PGA1_c11940 thymidine phosphorylase DeoA (Phaeobacter inhibens DSM 17395)
MDARAIIASLRRGDTPSDADLRWFAEGLANGTVSDAQAGAFAMAVCLQGLGVEARGALTL
AMRDSGDVLRWDLDGPVLDKHSTGGVGDCVSLLLAPALAECGAYVPMISGRGLGHTGGTL
DKMEAIPGVSIQVSEQDLVAMMQGVGCAIVGATAQIAPADKRLYAIRDVTATVDSLDLIT
ASILSKKLAASTDALVLDVKIGSGAFMKTLEEAEALALSLTETANAAGCRTSALITDMNQ
PLAPALGNALEVAEVMRVLTGVSGQGGALTELTAEQGGVLLAHGGLAADAEAGAEMIRKA
IASGAVAERFARMVAAMGGSSDFAETWQTILPTAPVQRRIKVEQTGYVSAIDGEALGLAV
VQLGGGRMIESDVVDPAVGLSELTPLGQKLSVGDQLGIVHAADEAAADVAETRLRAAYQL
SDAAPDLPPLIYKRIS