Protein Info for HP15_116 in Marinobacter adhaerens HP15

Annotation: two-component sensor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 transmembrane" amino acids 26 to 49 (24 residues), see Phobius details amino acids 171 to 196 (26 residues), see Phobius details PF02518: HATPase_c" amino acids 352 to 454 (103 residues), 63.2 bits, see alignment E=1.4e-21

Best Hits

Predicted SEED Role

"Sensor protein PhoQ (EC 2.7.13.3)" in subsystem Lipid A modifications (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJ61 at UniProt or InterPro

Protein Sequence (455 amino acids)

>HP15_116 two-component sensor (Marinobacter adhaerens HP15)
MLSTEPFRSIDKSTLMTAQKSIRKTALQYGMVFSILYFLLIFFSHTYVIEELSNESRKHR
LDKEVESFQTIIANEMPTADEIGSMIDQFQLLLEHALIVEMKDGSVIASNNVNQTKLRMI
SEKPAGFVEISHGADRLLGLKRGVGIDSSLSSITILEMESGLAERSSGAHLTLLAASAIL
LVVLLALVGTTTYLALKPIEHIKEDMRRLQSGKQPRLNPDAPEEFSPLIKQFNNLLELAS
RRLDRHRRLNSDLSHMVKTSISANLAILSDTGSLPPSRDDIEFMTSNLKDLSRSLNYRMS
KADISGRQMGQTCLPIEIANNVISVMEKIFPDKSFRINTSLPNNFSWPMERQDLSELFGN
LLENGGKWSQAEIDVSISQTDSGLTIEVADDGPGITPEAASKVMDRGSRLDETVSGFGLG
LSIVSEILEDNFGRMNIGPSETGGARITVVLPFPE