Protein Info for PGA1_c11660 in Phaeobacter inhibens DSM 17395

Annotation: molybdenum-containing hydroxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 766 PF01315: Ald_Xan_dh_C" amino acids 21 to 140 (120 residues), 69.4 bits, see alignment E=4.8e-23 PF02738: MoCoBD_1" amino acids 153 to 399 (247 residues), 241.3 bits, see alignment E=1.3e-75 PF20256: MoCoBD_2" amino acids 431 to 696 (266 residues), 255.6 bits, see alignment E=1e-79

Best Hits

KEGG orthology group: K03520, carbon-monoxide dehydrogenase large subunit [EC: 1.2.99.2] (inferred from 74% identity to sit:TM1040_1705)

Predicted SEED Role

"Possible hypoxanthine oxidase XdhD (EC 1.-.-.-)" in subsystem Purine conversions (EC 1.-.-.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.-.-.-, 1.2.99.2

Use Curated BLAST to search for 1.-.-.- or 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EYA8 at UniProt or InterPro

Protein Sequence (766 amino acids)

>PGA1_c11660 molybdenum-containing hydroxylase (Phaeobacter inhibens DSM 17395)
MMDKFGKSQPVRRVEDIRFLTGQGRYLEDAAPVGALRAWVLRSPVAHGTITHLDLDMARE
AEGVQAILTLADLEAAGINVGMDGAVVDNRDGSKAAAPERPMLVRDRVRFVGEPIAVVIA
ETLEQARDAGEMIELDIDDLPAKVDLTAGGEQLHAEAPDNRAFDWSMGDEAATEAAFASA
AHRVALQVEDNRIIVNTMEPRGCFATWAEGRLQFTYGGQGVWAMKKQLSDKLGLASEAVH
VTTPDVGGGFGMKAMPYPEYFAVAHAARLLGGPVFWMSDRSEAMLSDNAGRDLTSLAELA
FDADLRITGYRVHSHCNLGAYNSHFGQPVQTQLFSRVLAGVYDIDTTWLRVEGIYTNTAQ
VDAYRGAGRPEAIYVLERVMDHAARELGVDPWELRRRNFIRADQFPYKTATDETYDVGDF
HQLLTLTEEAADLAGFAQRKAADALRGNLRGVGLCYYIESILGDPSESAEVAFEEEGRVS
IYVGTQSNGQGHETVYAQFLADQTGIPAADITVVQGDSDRIAQGGGTGGSRSVTTQANAT
LAAVDVMIEAFTPFLAEQLGVAPASVVFDGEQFSAPGSNQRPTLVEAAEMARAQGRHELL
RHTARAKLPGRSFPNGAHVAEIVIDPETGVSHVDRYTVVDDFGNLINPLLAEGQVHGGVA
QGLGQALLERVVYDADGQLLTASFMDYALPRAADVPMIDVGFAPVPSTQNPMGMKGCGEA
GTVGALAAVANAVQDAVWDRGVRQVEMPYTPLRLWEALRNVADAAE