Protein Info for HP15_115 in Marinobacter adhaerens HP15

Annotation: heavy metal efflux pump, CzcA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1065 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 353 to 372 (20 residues), see Phobius details amino acids 379 to 398 (20 residues), see Phobius details amino acids 404 to 425 (22 residues), see Phobius details amino acids 475 to 495 (21 residues), see Phobius details amino acids 507 to 533 (27 residues), see Phobius details amino acids 565 to 584 (20 residues), see Phobius details amino acids 900 to 919 (20 residues), see Phobius details amino acids 926 to 945 (20 residues), see Phobius details amino acids 952 to 973 (22 residues), see Phobius details amino acids 1001 to 1022 (22 residues), see Phobius details amino acids 1029 to 1053 (25 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1056 (1056 residues), 1070.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 7 to 1055 (1049 residues), 915.7 bits, see alignment E=3.5e-279 PF03176: MMPL" amino acids 849 to 1061 (213 residues), 30.5 bits, see alignment E=1.8e-11

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 84% identity to kko:Kkor_1264)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJ60 at UniProt or InterPro

Protein Sequence (1065 amino acids)

>HP15_115 heavy metal efflux pump, CzcA family (Marinobacter adhaerens HP15)
MFNRVVDWAVQNRLLVLIALAVLIATAAFQIPKLNLDAFPDVTNVQVAVNTEAPGLAAEE
VEQLITYPIEAVMYALPDVEEVRSISKTGLSGVTVVFKEGTDIYFARQLVFERLQAAREL
IPDGVGVPEMGPNTSGLGQVYQYLLIADPNSGYDAMELRSLHDWLVKLLLIPAEGVTEIL
SFGGEVRQYQVNLNPARMLSYDLSQNDVMHALENNNSNVGGWYMGRGQEQLVIRGMGWLG
NGEQGLEQIRQVPVKTSDGITVTVDDVAQVGLGTEIRQGAVTMTRKDEDGQVEQLGEVVS
GIVLKRMGANTKATIDGIEARIERINQALPSGVRFEPYYNQADLVTKAVETVTNALLLAF
VFIAIVLALFLMNLRATTLVLLSIPISIGIALMIMAWFGLSANLMSLGGIAVAIGMLVDG
SVVMVENMFKHLTHPDAEHDAHRDELIENDPDPLDASHDDHGIALRLQEAGREVARPIFF
ATAIILVVFMPLFSFEGVEAKLFQPMAISIMLAIVSAVIVALIVVPALASFVFRKGIRER
ESFVLKPLEKLYRQGLDWSLKHTRSVVGAAAVLVVLAALVVPRLGTEFVPELEEGTINLR
VTLAPSSSLDTAIEVAPKLEAMLMEFPEVTYALSRAGRAEIGGDPEPVNNIEIYIGLKPT
SEWTSASNRYELQALFEEKLEQHPGLLFNFSQPIATRVDELLSGVRAQLAIKLFGPDLDV
LAEKGQQIEAAVRTVQGTRDVAMEQIAGEAQLVVQPDRQALSRYGLAVSDVMSVVRDGLG
GAAAGQIINGNERYDIYVRLAKRFREDRDAIADLRLQAPSGAWVRLGDVADVSIESGPPQ
VRRDDVQRRVVIQSNVQGRDMGSVVADIQDTIASEVNLPPGYSVDIGGQFENQQRAQKRL
AIVVPVSLGLIALLLYFAFSSVGQALLILVNVPLAVIGGVFSLWISGQYLSVPSSVGFIT
LFGVAVLNGVVMVESINQRIQDGLSVDAAVFEGAVSRLRPVLMTAITSALGLIPMLLSTG
VGAEIQKPLASVIVGGLVTATFLTLFVLPALFTRFSRAKLDDMQR