Protein Info for HP15_110 in Marinobacter adhaerens HP15

Annotation: heavy metal efflux pump, CzcA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 346 to 362 (17 residues), see Phobius details amino acids 369 to 388 (20 residues), see Phobius details amino acids 395 to 420 (26 residues), see Phobius details amino acids 444 to 465 (22 residues), see Phobius details amino acids 477 to 502 (26 residues), see Phobius details amino acids 535 to 554 (20 residues), see Phobius details amino acids 868 to 890 (23 residues), see Phobius details amino acids 897 to 920 (24 residues), see Phobius details amino acids 926 to 948 (23 residues), see Phobius details amino acids 969 to 988 (20 residues), see Phobius details amino acids 1000 to 1023 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1033 (1033 residues), 1130.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1026 (1022 residues), 980.1 bits, see alignment E=1.2e-298 PF03176: MMPL" amino acids 333 to 533 (201 residues), 20.8 bits, see alignment E=1.7e-08 amino acids 810 to 1024 (215 residues), 26.4 bits, see alignment E=3.3e-10

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 47% identity to gca:Galf_0858)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJ55 at UniProt or InterPro

Protein Sequence (1035 amino acids)

>HP15_110 heavy metal efflux pump, CzcA family (Marinobacter adhaerens HP15)
MINAIVNYALNNRLMTLVFAIAVIVAGIFSFQKLPVDAFPDATPTMVQVFTTSPGLSPVD
IETLISYPVEISMYGIPKLEKVQSTSIFGLSRVTIYFEDGTDIYFARRLVNERLSEAKRQ
IPEGMGEPELGPIASGLGRILMYSLETEDKEQYSLQEIRTIQDWIVKPQLRTVPGVTGVL
SIGGEVKQYQVNIDAQELQARNLTVSDIRGALTQNNRNVGASFITRGGEEYIVRGYGWVD
SGYEGIEDIQNIIVSKSEGESPIYVKDVAEVGLGPAIRRGAEVSSGEESVGGYVMKLIGT
NTSQVLEDVNAKIDDLNKSLPEGLKIEAYYSQADLVGKAIGTVEKALLEGSVLVLVFLYL
FLGNVRSTLIVVATLPLSVLFAFIAMRMSGLSANLMSLGGLAIGIGMMVDGAVVMIENIF
RHLEERSDEKVSVLRLVGESAREVARPIVFAIGIIIIVFLPLFTLQGVEGKLFSPMAYTI
SFALIGALLLALTLVPVLASLSFKMGGQHKEPKLVLFLNRLYKPVVNTVVKVPKIVMGVA
VVAFAGSLLLFPYLGSEFVPTLREGTFQIRSTLPPGASLESAIKYGKRIQSVVDEFPEVT
GTYARIGRAEVGGDPEPVNVVATLVNLKPLDQWREDVSYEDLQSRIAEALDERVPGLANN
LSQPIQLRTDELLSGVQAQLVASIFGDDLDELGRIGREVAALANDVPGATDVRAQQSAGK
KQIVIRPDREVLAQFGISIDNLMSTVETGIGGKSAGLVFDGVRRFEIFARLQESYRGSID
EIRKLPLRGNSGELIPLSRVADVEMYAGPKKISRSNASRRQYVQMNVRGRDMGSVVQDLR
NRIEKQVDMPPGYFVEFGGQFENQERAMARLAIVVPITLALIFLLLFSAFSSLRYAALIF
MNVPFAVTGGIVALFVTGLYLSVPAAVGFIAVFGVAVLNGVVMVSYINQLRDEGYEVIEA
VKLGAQRRLRPVLMTASVAILGLIPLLLADGIGSNVQRPLATVVVGGLITSTLLTLVVLP
SVYQWFASERRDVEV