Protein Info for Psest_1121 in Pseudomonas stutzeri RCH2

Annotation: Hypoxanthine-guanine phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00156: Pribosyltran
  • amino acids 18 to 169 (152 residues), 86.5 bits, E=6.3e-29

Best Hits

KEGG orthology group: K00760, hypoxanthine phosphoribosyltransferase [EC: 2.4.2.8] (inferred from 98% identity to psa:PST_3174)

Predicted SEED Role

"Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)" in subsystem Purine conversions (EC 2.4.2.8)

MetaCyc Pathways

• superpathway of purine nucleotide salvage (11/14 steps found)
• adenine salvage (2/3 steps found)
• guanine and guanosine salvage I (1/2 steps found)
• guanine and guanosine salvage II (1/2 steps found)
• xanthine and xanthosine salvage (1/2 steps found)
• adenine and adenosine salvage III (2/4 steps found)
• superpathway of guanine and guanosine salvage (1/3 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.8

Sequence Analysis Tools

See L0GJV0 at UniProt or InterPro

Protein Sequence (185 amino acids)

>Psest_1121 Hypoxanthine-guanine phosphoribosyltransferase (Pseudomonas stutzeri RCH2)
MSVDLAHIRQVMAEADCLYTEEQVEAAITSVAETINAKLADRNPVVFCVMNGGLIFSGKL
VPKLNFPLELSYLHATRYRNETSGGELFWKAKPEISFIDRDVLIIDDILDEGHTLGAIID
FCRHAGASAVHTAVLIDKDHQRKARPDLKADYVGLSCIDRYIFGYGMDYKGYWRNAPGIY
AVKGL