Protein Info for HP15_1047 in Marinobacter adhaerens HP15

Annotation: DNA mismatch repair protein MutS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 876 TIGR01070: DNA mismatch repair protein MutS" amino acids 11 to 871 (861 residues), 1223.7 bits, see alignment E=0 PF01624: MutS_I" amino acids 12 to 123 (112 residues), 144 bits, see alignment E=5.6e-46 PF05188: MutS_II" amino acids 132 to 257 (126 residues), 118.4 bits, see alignment E=7.4e-38 PF05192: MutS_III" amino acids 273 to 562 (290 residues), 178.3 bits, see alignment E=5.8e-56 PF05190: MutS_IV" amino acids 431 to 521 (91 residues), 112.4 bits, see alignment E=2.6e-36 PF00488: MutS_V" amino acids 613 to 800 (188 residues), 288 bits, see alignment E=9.4e-90

Best Hits

Swiss-Prot: 90% identical to MUTS_MARHV: DNA mismatch repair protein MutS (mutS) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 90% identity to maq:Maqu_2087)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PG68 at UniProt or InterPro

Protein Sequence (876 amino acids)

>HP15_1047 DNA mismatch repair protein MutS (Marinobacter adhaerens HP15)
MSAAQTDLSKHTPMMQQYLKIKGQHPNELVFYRMGDFYELFYEDAKKAAELMDITLTARG
QSGGNPIPMAGIPYHSSEGYIARLVRAGQSIAICEQIGDPATSKGPVDRQVVRIVTPGTL
SDDAYLEDRRDNLLVAIYNHREQFGFASLDISSGRFAVSELENLEALQGELQRLRPAEIL
ISEDFPYEDVLEGFTGIRRQGPWLFESDTARRVITHQLQVRDLTGFGCEELNLAVCAAGC
LLQYAKETQRTALPHIRKLTRERRDEAVILDAASRRNLEIDTNLMGGHQYTLAWVMDRTA
TSMGGRELRRWLNRPLRDVEIVRQRQQAVSALLDGFHYEPVHDLLKAVGDIERVLARVAL
RSARPRDLARLRDAFQALPDLQETLKPVNSHHVVRLATIIGEYPELADLLERAIIDNPPV
VIREGGVIREGFDEELDELRNISENAGQYLLDVETRERDRTGISTLKVGYNRVHGYYIEI
SRAQSDQAPVDYIRRQTLKNAERFITPELKEFEDKALSAKSRALAREKGLYDDVLETVAG
QLAPLQDAAQALAELDVLSNFAERATSLRFSAPEFSESPGFDIEEGRHPVVEQLLDEPFV
PNDLLMDTQRRMLVITGPNMGGKSTYMRQAALIALLAYTGSFVPANRAVIGPVDRIFTRM
GSSDDIAGGRSTFMVEMTETANILHNATEHSLVLMDEVGRGTSTFDGLSLAWATAEHLAR
EIRCYTLFATHYFELTQLADELQHAVNVHLTATEHDDSIVFLHNVHDGPASQSYGLQVAK
LAGVPQDVIRNAKTQLSHLEGSASPAAPAASAAEQGNNASLAKPATKVNESVYQGDMFAS
LEPSAVEEALKDMDLDGLTPRDAMNQLYELKALMKK