Protein Info for PGA1_c10490 in Phaeobacter inhibens DSM 17395

Annotation: NADH-quinone oxidoreductase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01971: NADH-quinone oxidoreductase, chain I
  • amino acids 21 to 142 (122 residues), 172.4 bits, E=1.2e-55
• PF00037: Fer4
  • amino acids 62 to 81 (20 residues), 25.7 bits, see alignment (E = 4e-09)
  • amino acids 98 to 119 (22 residues), 34.5 bits, see alignment (E = 6.7e-12)
• PF13237: Fer4_10
  • amino acids 62 to 115 (54 residues), 29.8 bits, E=2.6e-10
• PF12800: Fer4_4
  • amino acids 63 to 77 (15 residues), 17.1 bits, see alignment (E = 3e-06)
  • amino acids 102 to 116 (15 residues), 13.6 bits, see alignment (E = 4.1e-05)
• PF12838: Fer4_7
  • amino acids 64 to 118 (55 residues), 50.5 bits, E=1.3e-16
• PF13187: Fer4_9
  • amino acids 64 to 119 (56 residues), 35 bits, E=6.5e-12

Best Hits

Swiss-Prot: 96% identical to NUOI_RUEST: NADH-quinone oxidoreductase subunit I (nuoI) from Ruegeria sp. (strain TM1040)

KEGG orthology group: K00338, NADH dehydrogenase I subunit I [EC: 1.6.5.3] (inferred from 93% identity to rde:RD1_3275)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain I (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Sequence Analysis Tools

See I7EVJ2 at UniProt or InterPro

Protein Sequence (164 amino acids)

>PGA1_c10490 NADH-quinone oxidoreductase subunit I (Phaeobacter inhibens DSM 17395)
MANIDYTRAAKYFLLQDFWVGFKLGLKYFFAPKATLNYPHEKGPLSPRFRGEHALRRYPN
GEERCIACKLCEAVCPAQAITIDAEPREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIV
EGPNFEFATETREELFYDKDKLLSNGERWEAEIARNLELDAPYR