Protein Info for EX31_RS22805 in Rahnella sp. WP5

Annotation: multidrug efflux RND transporter permease AcrD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1051 signal peptide" amino acids 9 to 11 (3 residues), see Phobius details transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 386 (21 residues), see Phobius details amino acids 393 to 413 (21 residues), see Phobius details amino acids 440 to 460 (21 residues), see Phobius details amino acids 470 to 492 (23 residues), see Phobius details amino acids 541 to 559 (19 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 947 (25 residues), see Phobius details amino acids 971 to 992 (22 residues), see Phobius details amino acids 1003 to 1025 (23 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1027 (1027 residues), 1372 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1036 (1036 residues), 1733.3 bits, see alignment E=0 PF03176: MMPL" amino acids 287 to 518 (232 residues), 44.7 bits, see alignment E=1.4e-15

Best Hits

Swiss-Prot: 78% identical to ACRD_ECOLI: Probable aminoglycoside efflux pump (acrD) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 63% identity to abo:ABO_0964)

MetaCyc: 78% identical to multidrug efflux pump RND permease AcrD (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-1551; TRANS-RXN-1552; TRANS-RXN-360

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1051 amino acids)

>EX31_RS22805 multidrug efflux RND transporter permease AcrD (Rahnella sp. WP5)
MANFFIDRPIFAWVLAIIISLSGALAIYFLPVEQYPDLAPPNVRISATYPGASAQTLENT
VTQIIEQNMTGLDNLMYMSSQSSNDGKSQITLSFTAGTDPNEALQQVQNQLQQALKRLPQ
DVQTQGVTVSKTGDTNLMMVAFVSTDGSMDKQDIADYVASNIQDPLSRVPGVGSIDAYGS
QYAMRIWLDPDKLNNYQLTTADVVTAIKAQNSQVAVGQLGGAPSVDFQALNATINAQAQL
QTPEQFRQITLKVNQDGSQVKLGDVSTIGLGAENYALLSRYNGQAASGMGVKLASGANEL
QTDKAVRARLDELSHYYPHGLKAEIAYETTPFVKAAITDVVKTLFEAIVLVFLVMYLFLQ
NFRATLIPTIAVPVVLLGTFAVLHQFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERVM
SEEGLSPREATRKSMGQIQSALVGITMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVL
SVFVALTLTPALCSTILKPVAQGHHHGKRGFFGWFNRMFDRNARRYENGVARVLRNSLRY
MLGYAALVALLAVMFIKLPTSFLPMEDRGVFTVQVQLPPGSTLQQTQKVVEKVEKYFLTE
DKKDVLSVFSTIGAGPGGNGQNVARMFVRLTPWDARTGAGDSSFALIERATKAFNKITEA
RVIASSPPAINGLGSATGFDMELQDHAGLGHDALMAARDQLLAMTSKDSNLTRVRHNGLD
DSPQLQIDIDQVKAQALGVAISDINSTLSTAWGSTYVNDFVDRGRVKKVYVQAAAQYRML
PDDIDRWYVRNSAGTMVPFSAFATSKWLTGSPRLERYNGYSALEIVGEPATGISSGTAMD
DMEKLVAKLPVGIGLEWTGLSYQERLSGSQAPALYAISLLVVFLCLAALYESWSIPFSVM
LVVPLGVLGAVIATWLRGLENDVYFQVGMLTIIGLSAKNAILIVEFANDLNVRGKELLEA
TLEAARMRLRPILMTSLAFVFGVLPMATSMGAGSGSQHAVGTGVIGGMISATVLAIFFVP
LFFVLIRRRFPGKHTAPVIADIVETAPAEHR