Protein Info for EX31_RS21695 in Rahnella sp. WP5

Annotation: tagatose-bisphosphate aldolase subunit GatZ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08013: GatZ_KbaZ-like
  • amino acids 1 to 418 (418 residues), 634.9 bits, E=2.6e-195
• TIGR02810: D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
  • amino acids 3 to 418 (416 residues), 673.2 bits, E=7e-207

Best Hits

Swiss-Prot: 72% identical to GATZ_SALEP: D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ) from Salmonella enteritidis PT4 (strain P125109)

KEGG orthology group: K00917, tagatose 6-phosphate kinase [EC: 2.7.1.144] (inferred from 99% identity to rah:Rahaq_3462)

MetaCyc: 68% identical to putative tagatose-1,6-bisphosphate aldolase 2 chaperone (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Tagatose-6-phosphate kinase GatZ (EC 2.7.1.144)" in subsystem D-Tagatose and Galactitol Utilization (EC 2.7.1.144)

MetaCyc Pathways

• superpathway of hexitol degradation (bacteria) (18/18 steps found)
• galactitol degradation (5/5 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (3/4 steps found)
• N-acetyl-D-galactosamine degradation (3/5 steps found)
• lactose degradation I (2/5 steps found)

KEGG Metabolic Maps

• Galactose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.144

Protein Sequence (431 amino acids)

>EX31_RS21695 tagatose-bisphosphate aldolase subunit GatZ (Rahnella sp. WP5)
MKDIIAKHKTGERIGICSVCSAHPLVIEAALREDLHTGRKVLIEATSNQVNQFGGYTGML
PIDFRDFVLAIAEKIGFPLQRLILGGDHLGPNCWQHENAETAMAKAQELIARYVEAGFSK
IHLDASMSCADDPVPLDPFVVAQRAARLCQVAEEVATAQQKALLTYVIGTEVPVPGGESS
AIQHVHVTEAKDAKATLDMHHQAFRELGLNDAIDRIVAIVVQPGVEFDHSRVIHYQSDLA
QDLSAYIAATPLVYEAHSTDYQTRDSYRNLVKDHFAILKVGPALTFALREAVFALANIEQ
VLIAPECRSQILTVIDGVMLDEPGYWKKYYNPTFSLSLIDLHFSLSDRIRYYWPHTRINR
AMDVLMANLRSTDIPLGLLSQYLPAQFERVMNGELASDPHELIIDKIQDVLRAYHFGCTP
LQTICEGACHA