Protein Info for EX31_RS20305 in Rahnella sp. WP5

Annotation: DHA2 family efflux MFS transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 56 to 79 (24 residues), see Phobius details amino acids 86 to 104 (19 residues), see Phobius details amino acids 118 to 134 (17 residues), see Phobius details amino acids 148 to 161 (14 residues), see Phobius details amino acids 174 to 196 (23 residues), see Phobius details amino acids 208 to 225 (18 residues), see Phobius details amino acids 231 to 254 (24 residues), see Phobius details amino acids 273 to 293 (21 residues), see Phobius details amino acids 298 to 320 (23 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 364 to 383 (20 residues), see Phobius details amino acids 404 to 428 (25 residues), see Phobius details amino acids 442 to 462 (21 residues), see Phobius details PF05977: MFS_3" amino acids 13 to 186 (174 residues), 27.4 bits, see alignment E=1.2e-10 PF07690: MFS_1" amino acids 26 to 416 (391 residues), 162.6 bits, see alignment E=1.3e-51 TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 27 to 453 (427 residues), 231 bits, see alignment E=1.3e-72

Best Hits

Swiss-Prot: 76% identical to MDTD_SERP5: Putative multidrug resistance protein MdtD (mdtD) from Serratia proteamaculans (strain 568)

KEGG orthology group: None (inferred from 100% identity to rah:Rahaq_1081)

Predicted SEED Role

"Multidrug transporter MdtD"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (491 amino acids)

>EX31_RS20305 DHA2 family efflux MFS transporter permease subunit (Rahnella sp. WP5)
MKSENTDTLSPSTPLPPSVRWQLWIVAFGFFMQALDTTIVNTALPSMARSLGENPLHMHS
VIVAYVLTVAVMLPASGWLADKVGVKWVFFSAIVLFTLGSLLCAQSESLRELVMSRIVQG
IGGAMMVPVGRLTVLKIVPRSEYMAAMTMVTLPGQVGPLLGPALGGFLVQYASWHWIFLI
NLPVGLAGCIATLMIMPNYKMQTRRFDISGFVMLAVCMATLTLALEGSRSMGLTALEIVL
LVVAGGGALGIYWMHARGNLSALFSLRLFHTPTFKIGLIGSLLGRIGSGMLPFMTPVFLQ
LGMGFTPFHAGLMMIPMVLGSMGMKRVVVRLVNQLGYRSALVSATLLLALITLIFPLVAI
YGAMWMIPIVLFFQGMVNSLRFSSMNTLTLKDLPPRLASSGNSLLSMIMQLSMSLGVSVA
GLLIGLFAHQQAITPDSSTMHTAFLYCYMSMALVIALPAWVFSKVPPDTQKNAIISRRRA
EAGSPDPMRKS