Protein Info for EX31_RS19330 in Rahnella sp. WP5

Annotation: catalase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00199: Catalase
  • amino acids 9 to 389 (381 residues), 627.6 bits, E=8.6e-193
• PF06628: Catalase-rel
  • amino acids 416 to 477 (62 residues), 74.3 bits, E=6.9e-25

Best Hits

Swiss-Prot: 85% identical to CATA_PROMI: Catalase (katA) from Proteus mirabilis

KEGG orthology group: K03781, catalase [EC: 1.11.1.6] (inferred from 100% identity to rah:Rahaq_1282)

MetaCyc: 52% identical to catalase monomer (Homo sapiens)
Catalase. [EC: 1.11.1.21, 1.11.1.6]; 1.11.1.6 [EC: 1.11.1.21, 1.11.1.6]

Predicted SEED Role

"Catalase (EC 1.11.1.6)" in subsystem Oxidative stress or Photorespiration (oxidative C2 cycle) (EC 1.11.1.6)

MetaCyc Pathways

• reactive oxygen species degradation (4/4 steps found)
• ethanol degradation IV (3/3 steps found)
• superoxide radicals degradation (2/2 steps found)
• methanol oxidation to formaldehyde IV (1/2 steps found)

KEGG Metabolic Maps

• Methane metabolism
• Tryptophan metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.6

Use Curated BLAST to search for 1.11.1.21 or 1.11.1.6

Protein Sequence (479 amino acids)

>EX31_RS19330 catalase (Rahnella sp. WP5)
MFMTKKGLTTAAGAPVVDNNNVITAGRRGPLLLQDVWFLEKLAHFDREVIPERRMHAKGS
GAYGTFTVTHDITAFTRAKIFSAIGKQTDMFIRFSTVAGERGAADAERDIRGFSMKFYTE
EGNWDLVGNNTPVFYLRDPLKFPDLNHVVKRDPRTNLRNPAYKWDFFSHLPEALHQLTID
VSDRGLPTSYRHIHGFGSHTFSFINTENERFWVKFHFRCQQGIENLMDDEAEKLVGTDRE
SSQRDLYEAIERGDFPRWKLFVQIMPEADAAKLPYNPFDLTKVWLHSDYPLIEVGEFELN
RNPENYFAEVEQVAMSPANVVPGIGFSPDRMLQGRLFSYGDAHRYRLGVNHHQIPVNAPK
CPFHNYHRDGAMRVDGNSGNGVTYEPNSAGLFQQQPDFSEPPLSIEGAADHWNHREDDDY
FTQPRLLFNLLSEAEHQRMFARIAGELKHASPETQARQLALFYKVDPAYGAGVEKALKD