Protein Info for EX31_RS16635 in Rahnella sp. WP5

Annotation: gluconate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 5 to 22 (18 residues), see Phobius details amino acids 28 to 49 (22 residues), see Phobius details amino acids 59 to 79 (21 residues), see Phobius details amino acids 103 to 132 (30 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 175 to 199 (25 residues), see Phobius details amino acids 225 to 247 (23 residues), see Phobius details amino acids 262 to 281 (20 residues), see Phobius details amino acids 293 to 316 (24 residues), see Phobius details amino acids 329 to 351 (23 residues), see Phobius details amino acids 358 to 377 (20 residues), see Phobius details amino acids 383 to 408 (26 residues), see Phobius details amino acids 420 to 443 (24 residues), see Phobius details PF02447: GntP_permease" amino acids 5 to 441 (437 residues), 485.5 bits, see alignment E=1.4e-149 TIGR00791: transporter, gluconate:H+ symporter (GntP) family" amino acids 5 to 444 (440 residues), 497.3 bits, see alignment E=2.2e-153 PF03600: CitMHS" amino acids 18 to 390 (373 residues), 47 bits, see alignment E=2e-16

Best Hits

Swiss-Prot: 71% identical to GNTU_ECOLI: Low-affinity gluconate transporter (gntU) from Escherichia coli (strain K12)

KEGG orthology group: K06156, Gnt-I system low-affinity gluconate transporter (inferred from 90% identity to srs:SerAS12_4596)

MetaCyc: 71% identical to low-affinity gluconate transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-209

Predicted SEED Role

"Low-affinity gluconate/H+ symporter GntU" in subsystem D-gluconate and ketogluconates metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>EX31_RS16635 gluconate transporter (Rahnella sp. WP5)
MNTVTLVGTAAGSVLLLLFLVMKVRMHAFVALMLVSIAAGIFSGMPVNTIADTMQKGMGS
TLGFLAIVVALGAMFGKILHEVGALDQIAAHLLNRFGKNKAHYALGIAGLVCALPLFFDV
AIVLLIGIVFAVARRTDGNIVRLAIPLFAGVAAAACFLLPGPVPMLLASQMNADFGWMIA
IGLVAAIAGMLIAGPLYGNFISRHVSWPMPVEENAPTLNKDNLPSFGFSLALILCPLVLV
GMKTIGARFVTAGTPLHDWLEFIGHPFTAILIACLIVIYGLAKPRGMTNEQTLAICSAAV
QPAGIILLMTGAGGVFKQILVDSGVGPAIGDAMIGTGLPIAVACFALSAVVRVIQGSATV
ACLTTVGLVLPVTHQMGLNGGQLAALAICITGGSIVLSHVNDAGFWLFGKFTGASELQTL
KTWTVMETLLGTTGGIIGMIAFTML