Protein Info for EX31_RS16515 in Rahnella sp. WP5

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 352 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 38 to 57 (20 residues), see Phobius details amino acids 65 to 83 (19 residues), see Phobius details amino acids 89 to 117 (29 residues), see Phobius details amino acids 128 to 146 (19 residues), see Phobius details amino acids 152 to 174 (23 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 189 to 346 (158 residues), 160.6 bits, see alignment E=1.4e-51 PF00990: GGDEF" amino acids 192 to 343 (152 residues), 136.5 bits, see alignment E=3.7e-44

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (352 amino acids)

>EX31_RS16515 GGDEF domain-containing protein (Rahnella sp. WP5)
MDFIELTFINTLVGICITYTCISIPLINYSSALSEHVSLKILLGIVLGLASIYLFNIGEQ
HNTSIYSVVISPITFGLIIFGYPTFFASLIVSAVFLFGISTFYDAFSLVYFVMLLLFNIR
GRMRVRYVIYSYCIAQAFNVLTHFSVLNENGYWALAIIKTIMSLLYILLVYVLLNNLINL
SKRELFFKKASKTDPLTGINNRRSIDAYIESLNECYGEKFCVFMLDIDNFKYLNDNFGHP
FGDKVIKRVAYLVKKNVRENDFVGRYGGEEFIVFINADLQNATKIAEDIRMVIQNSNIKF
DSQEVHVTVSIGLSEHADTQSVLETITAADNALYTAKRSGKNKIMILSGSVA