Protein Info for EX31_RS13235 in Rahnella sp. WP5

Annotation: molybdopterin-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF18364: Molybdopterin_N
  • amino acids 9 to 48 (40 residues), 57.7 bits, 1.3e-19
• PF00384: Molybdopterin
  • amino acids 52 to 508 (457 residues), 172.4 bits, E=2.2e-54
• PF01568: Molydop_binding
  • amino acids 625 to 745 (121 residues), 89.1 bits, E=2.9e-29

Best Hits

Swiss-Prot: 48% identical to BISC_RHOSH: Biotin sulfoxide reductase from Rhodobacter sphaeroides

KEGG orthology group: K08351, biotin sulfoxide reductase [EC: 1.-.-.-] (inferred from 100% identity to rah:Rahaq_0826)

MetaCyc: 48% identical to biotin sulfoxide reductase (Cereibacter sphaeroides)
1.8.4.-

Predicted SEED Role

"Anaerobic dimethyl sulfoxide reductase chain A (EC 1.8.5.3)" (EC 1.8.5.3)

MetaCyc Pathways

• NADH to dimethyl sulfoxide electron transfer (2/2 steps found)
• formate to dimethyl sulfoxide electron transfer (2/2 steps found)
• hydrogen to dimethyl sulfoxide electron transfer (1/2 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis I
• Carotenoid biosynthesis - General
• Insect hormone biosynthesis
• Nucleotide sugars metabolism
• Porphyrin and chlorophyll metabolism
• Puromycin biosynthesis
• Trinitrotoluene degradation
• alpha-Linolenic acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.-.-.-, 1.8.5.3

Use Curated BLAST to search for 1.-.-.- or 1.8.5.3

Protein Sequence (752 amino acids)

>EX31_RS13235 molybdopterin-dependent oxidoreductase (Rahnella sp. WP5)
MSIKRYPQLAHWGAYTAVVEDGRLIRCEPYKADADPSPLLDSIAPLVYSDKRIRKPAVRR
SWLKHRENSDRSLRGREDFVEVDWDLALDLVAEENKRVRDRYGASGIFNGSYGWSSAGRL
HHARSLVRRFYFTGGGGVDQQGNYSWGSAQFFLPYVIGTFTPLTGRVTSWPSVVEHADIL
VAFGGLALKNAQVASGGAVEHTLKPALEQLAKKGTRVINISPMRDDCPEFVNAEWIPIRP
NTDAALMMAVAFEIQRKEAQDEAFLTSHCVGYPQLAAYLRGDTDGIPKTPDWASHITGVP
AERIARLADDLIGVRSFITCSYSVQRAHRGEQPYWMMIAISAMLGQVGLPGGGFSFGHGS
MNSVGNPRYDTPGPAVSAGPNPSGLSIPVARISDMLLNPGQPYEFQGETLNYPDIHLVHW
AGGNPFHHHQQLNRLVEGWQKPDTVIVQDNVWTPAAQMADIVLPATTSLERNDIGGSSRD
RFVLAMHQAVAPQHQARNDFDIFADIADRLGYREQFTQGRNEDQWLRHIYRQCGEAQKGT
GVEWPDFETFWERGFVELPVPEKDYVFFEEFRKSPRANPLGTHSGKIELFSETIAGYGYD
DFAPHPEWQPPVEWLGAESAKQWPLHLISIQPKDRLHSQLDQSPLAQSNKTAGKETLFMH
PEDALSRQLKEGDRVKVHNARGSCLAGVSLSDGITRGVVLMSTGAWFDPGFGGRWQETEQ
AGNPNVLTLDIGTSRLTQGPNAMSCLVEVGPV