Protein Info for EX31_RS13210 in Rahnella sp. WP5
Annotation: DNA mismatch repair endonuclease MutH
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 79% identical to MUTH_ECOLU: DNA mismatch repair protein MutH (mutH) from Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
KEGG orthology group: K03573, DNA mismatch repair protein MutH (inferred from 100% identity to rah:Rahaq_0831)MetaCyc: 78% identical to DNA mismatch repair protein MutH (Escherichia coli K-12 substr. MG1655)
Predicted SEED Role
"DNA mismatch repair endonuclease MutH" in subsystem DNA repair, bacterial
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (228 amino acids)
>EX31_RS13210 DNA mismatch repair endonuclease MutH (Rahnella sp. WP5) MSIPLPATQPPHNEQQLLHRAQSLAGHTLGELAAHAGLPIPENLKREKGWVGMLLEVYLG AIAGSKPEQDFADIGIELKTIPIDSRGRPLETTFVCVAPLTGNSGVTWENSHVRHKLARV LWIPVEGERQIPLAERHIGAPLLWQPSEEEDEQLRQDWEELMDLIVLGKVESITARHGEY LQIRPKAANSKALTEAIGESGQPILTLPRGFYLKKRFTAALLARHFQL