Protein Info for EX31_RS13040 in Rahnella sp. WP5

Annotation: type I methionyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 3 to 250 (248 residues), 351.1 bits, E=1.7e-109
• PF00557: Peptidase_M24
  • amino acids 12 to 242 (231 residues), 166.5 bits, E=3.8e-53

Best Hits

Swiss-Prot: 84% identical to MAP1_SALTI: Methionine aminopeptidase (map) from Salmonella typhi

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 100% identity to rah:Rahaq_0862)

MetaCyc: 85% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (4/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Protein Sequence (263 amino acids)

>EX31_RS13040 type I methionyl aminopeptidase (Rahnella sp. WP5)
MAISIKTPEDIEKMRVAGRLAAEVLEIIEPFVKPGVSTGELDRICADHIVNKQQAVSACL
DYHGFPKSVCISVNEVVCHGIPSEDKILKDGDIVNIDVTVIKDGFHGDTSKMFIAGKPTI
LGERLCRITQESLYIALRLIKPGIRLRTLGKEIQKFVEAEKFSVVREYCGHGIGEGFHEE
PQVLHYDADDGGVVLQAGMAFTVEPMVNAGDYRIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEIMTLRKDDTIPAILTHD