Protein Info for EX31_RS11155 in Rahnella sp. WP5

Annotation: DHA2 family efflux MFS transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 transmembrane" amino acids 20 to 43 (24 residues), see Phobius details amino acids 58 to 79 (22 residues), see Phobius details amino acids 87 to 110 (24 residues), see Phobius details amino acids 112 to 113 (2 residues), see Phobius details amino acids 119 to 136 (18 residues), see Phobius details amino acids 146 to 170 (25 residues), see Phobius details amino acids 176 to 197 (22 residues), see Phobius details amino acids 207 to 227 (21 residues), see Phobius details amino acids 234 to 252 (19 residues), see Phobius details amino acids 273 to 296 (24 residues), see Phobius details amino acids 307 to 325 (19 residues), see Phobius details amino acids 337 to 358 (22 residues), see Phobius details amino acids 364 to 380 (17 residues), see Phobius details amino acids 408 to 428 (21 residues), see Phobius details amino acids 435 to 456 (22 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 21 to 421 (401 residues), 243.3 bits, see alignment E=2.5e-76 PF07690: MFS_1" amino acids 25 to 414 (390 residues), 179.4 bits, see alignment E=9.8e-57 PF06779: MFS_4" amino acids 58 to 191 (134 residues), 27.4 bits, see alignment E=2.2e-10

Best Hits

KEGG orthology group: K08169, MFS transporter, DHA2 family, multidrug resistance protein (inferred from 99% identity to rah:Rahaq_1876)

Predicted SEED Role

"Multidrug resistance protein B"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (460 amino acids)

>EX31_RS11155 DHA2 family efflux MFS transporter permease subunit (Rahnella sp. WP5)
MSLVSSSPLEQGFEAPRRYLAAAAILIGVVMAALDSSIVNISLPSIAEALRVDSASVIWV
TNAYQVASAATMLICASLGSRIGERRFYTAGMVLFTLASLGCSLSPTFGMLVAMRILQGV
SYAVMISVGLGLYRVIFPPHTLGTILGLNALAFAVGTAIGPALGGLIISYLDWPWLFYIN
LPLGALAIVFSLISLGVDTEKEKGFDWGGAVTSAVALGLMVIAVDQIGRWDSRILMLCGA
ASVLLLAIFVSVQTRSKSPLLPLDIFRSRRYTFAVISSVSMFVAQGMALVGLPFVLQHAY
HYSVLESAFIFTPWPVAVAICAPVAGRLSNRLNPTQISTAGVVIFSLGLGSLALLPQVAT
VNDFLWRVAVCGIGYGLFLPPNNKEMFSNVAPNRTVTASGVLSTARTAGQSIGAALVAMV
IALLNGLTGQAGAQFAVYVFGLACFISALSSVSSMLRLHR