Protein Info for EX31_RS09890 in Rahnella sp. WP5

Annotation: HTH-type transcriptional regulator CysB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 324 PF00126: HTH_1" amino acids 3 to 64 (62 residues), 52.6 bits, see alignment E=3.7e-18 PF03466: LysR_substrate" amino acids 92 to 293 (202 residues), 149.1 bits, see alignment E=1.2e-47

Best Hits

Swiss-Prot: 93% identical to CYSB_ECO57: HTH-type transcriptional regulator CysB (cysB) from Escherichia coli O157:H7

KEGG orthology group: K13634, LysR family transcriptional regulator, cys regulon transcriptional activator (inferred from 100% identity to rah:Rahaq_2604)

MetaCyc: 93% identical to DNA-binding transcriptional dual regulator CysB (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Cys regulon transcriptional activator CysB" in subsystem Cysteine Biosynthesis or DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

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Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

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Find the best match in UniProt

Protein Sequence (324 amino acids)

>EX31_RS09890 HTH-type transcriptional regulator CysB (Rahnella sp. WP5)
MKLQQLRYIVEVVNHNLNVSSTAEGLYTSQPGISKQVRMLEDELGIQIFSRSGKHLTQVT
PAGQEIIRIAREVLSKVDAIKAVAGEHTYPDKGSLYVATTHTQARYALPNVIKGFIERYP
RVSLHMHQGSPTQIAEAVSKGNADFAIATEALHLYDDLIMLPCYHWNRAVVVQPDHPLAG
KEKVTIEELAAYPIVTYTFGFTGRSELDTAFNRAGLTPRIVFTATDADVIKTYVRLGLGV
GVIASMAVDPVQDPDLVTVDASDIFTYSTTKIGFRRSTFLRSYMYDFIQRFAPHLTRDVV
DTAISLRSNEDIEEMFKDIKLPTK